| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| Other Sizes |
| Targets |
11alpha-Hydroxyprogesterone targets steroid hormone pathways as a precursor to cortisol and aldosterone. As a hydroxylated progesterone derivative, it may interact with steroid hormone receptors or serve as a substrate for enzymes involved in steroidogenesis, including 11β-hydroxylase and other cytochrome P450 enzymes. The 11α-hydroxyl group distinguishes it from progesterone and other related steroids, potentially affecting its receptor binding and biological activity. However, specific molecular targets have not been extensively characterized.
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|---|---|
| ln Vitro |
In vitro, 11alpha-Hydroxyprogesterone is a steroid hormone and a precursor to other hormones such as cortisol and aldosterone. As a naturally occurring steroid, it may exhibit hormonal activity or serve as a substrate for steroidogenic enzymes in cell-based assays. The compound is used as a reference standard in analytical method development for progesterone and related steroids. However, detailed in vitro activity data including receptor binding affinities or enzyme kinetic parameters have not been extensively published.
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| ln Vivo |
In vivo, 11alpha-Hydroxyprogesterone is produced naturally in the body as a precursor to other hormones such as cortisol and aldosterone. It is a naturally occurring steroid hormone and a metabolite of progesterone. The compound plays a role in the steroidogenic pathway leading to the production of glucocorticoids and mineralocorticoids. However, its specific physiological functions and therapeutic applications have not been extensively characterized in the published literature.
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| Enzyme Assay |
In vitro assays for 11alpha-Hydroxyprogesterone are not extensively documented for pharmacological evaluation. As a steroid hormone and analytical standard, the compound can be analyzed by HPLC or GC for quality control and method development purposes. Receptor binding assays for steroid hormone receptors could potentially be used to evaluate its activity. The compound's purity is confirmed by GC with purity ≥95.0%. Melting point: 167.0 to 170.0°C.
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| Cell Assay |
In vitro cellular assays for 11alpha-Hydroxyprogesterone are not extensively documented. As a steroid hormone, potential cellular assays could include evaluation of its effects on steroid receptor-expressing cells, assessment of its metabolism by steroidogenic enzymes, or measurement of its hormonal activity. The compound appears as a white to off-white solid powder to crystal and is stored at room temperature in a cool and dark place (<15°C).
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| Animal Protocol |
In vivo animal experiments for 11alpha-Hydroxyprogesterone are not extensively reported. As a naturally occurring steroid hormone and precursor to cortisol and aldosterone, it may be studied in the context of steroidogenesis and adrenal function. However, specific in vivo study protocols and results have not been published for this compound. The compound is used as an analytical standard for method development and quality control.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of 11alpha-Hydroxyprogesterone are characteristic of steroid hormones. The compound has a molecular weight of 330.47 g/mol and a molecular formula of C₂₁H₃₀O₃. As a lipophilic steroid, it is expected to have good membrane permeability and tissue distribution. The compound appears as a white to off-white solid powder to crystal with a melting point of 167.0 to 170.0°C. Storage: room temperature in a cool and dark place (<15°C). Purity (GC) ≥95.0%.
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| Toxicity/Toxicokinetics |
The toxicological profile of 11alpha-Hydroxyprogesterone has not been extensively documented. As a naturally occurring steroid hormone, it is expected to have a favorable safety profile at physiological concentrations. However, comprehensive toxicological evaluations including acute toxicity, genotoxicity, and repeated-dose studies have not been reported. Standard laboratory safety precautions should be followed when handling this compound.
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| References |
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| Additional Infomation |
11α-Hydroxyprogesterone is an 11α-hydroxy steroid with the structure pregn-4-en-3,20-dione, where the hydroxyl group at position 11 is substituted. It is an 11α-hydroxy steroid, a 3-oxo-Δ(4) steroid, and a 20-oxo steroid. Its function is related to progesterone.
See also: 11α-Hydroxyprogesterone (note moved to). 11alpha-Hydroxyprogesterone (CAS# 80-75-1, molecular formula C₂₁H₃₀O₃, molecular weight 330.47) is a naturally occurring steroid hormone and precursor to cortisol and aldosterone. Also known as 11α-hydroxyprogesterone and 4-pregnen-11α-ol-3,20-dione. Used as an analytical standard. No clinical trials or regulatory approvals have been identified. Purity (GC) ≥95.0%. Storage: room temperature in a cool and dark place (<15°C). |
| Molecular Formula |
C21H30O3
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|---|---|
| Molecular Weight |
330.46
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| Exact Mass |
330.219
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| CAS # |
80-75-1
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| Related CAS # |
11beta-Hydroxyprogesterone;600-57-7
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| PubChem CID |
92730
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| Appearance |
White to off-white solid powder
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| Density |
1.15 g/cm3
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| Boiling Point |
487.4ºC at 760 mmHg
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| Melting Point |
165-166ºC(lit.)
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| Flash Point |
262.7ºC
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| Index of Refraction |
1.557
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| LogP |
3.694
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
24
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| Complexity |
621
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| Defined Atom Stereocenter Count |
7
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| SMILES |
C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@H](C(=O)C)[C@]3(C[C@H]([C@H]21)O)C
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| InChi Key |
BFZHCUBIASXHPK-QJSKAATBSA-N
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| InChi Code |
InChI=1S/C21H30O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h10,15-19,24H,4-9,11H2,1-3H3/t15-,16+,17-,18+,19+,20-,21+/m0/s1
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| Chemical Name |
(8S,9S,10R,11R,13S,14S,17S)-17-acetyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~302.6 mM; with ultrasonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.57 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.57 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (7.57 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0261 mL | 15.1304 mL | 30.2608 mL | |
| 5 mM | 0.6052 mL | 3.0261 mL | 6.0522 mL | |
| 10 mM | 0.3026 mL | 1.5130 mL | 3.0261 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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