| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 500mg | |||
| 1g | |||
| Other Sizes |
| Targets |
Quercetin 3-O-(6''-O-galloyl)-β-D-glucoside targets oxidative stress and inflammatory pathways. As a flavonoid, it exhibits antioxidant activity through free radical scavenging and metal chelation. The galloyl moiety may enhance its biological activities. The compound may modulate signaling pathways involved in inflammation and cancer cell proliferation. However, specific molecular targets are not fully characterized.
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|---|---|
| ln Vitro |
Quercetin 3-O-(6''-O-galloyl)-β-D-glucoside (Tellimoside) inhibits M.aeruginosa growth far more than Quercetin, despite having the quercetin moiety as the glucoside's aglycone. Tellimoside's galloyl and sugar groups give the compound more polarity, which makes it easier for the glycoside to migrate to M. aeruginosa in the aquatic system[1].
In vitro, Tellimoside exhibits antioxidant, anti-inflammatory, and anticancer activities. Specific IC50 values are not detailed in the available literature. As a galloylated flavonoid, it is expected to have potent antioxidant activity. The compound is used in research on oxidative stress, inflammation, and cancer. |
| ln Vivo |
Specific in vivo data for Tellimoside are limited. Given its in vitro activities, the compound has potential for in vivo studies in models of oxidative stress, inflammation, and cancer. However, specific published in vivo protocols for this compound are not available.
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| Enzyme Assay |
The antioxidant activity is assessed using standard in vitro assays such as DPPH, ABTS, or FRAP. Anti-inflammatory activity is assessed by measuring cytokine production in LPS-stimulated immune cells. Anticancer activity is assessed using cell viability assays in cancer cell lines. The compound has a molecular formula of C₂₈H₂₄O₁₆ and a molecular weight of 616.48 g/mol.
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| Cell Assay |
For cellular studies, appropriate cell lines (e.g., cancer cells, immune cells) are cultured in suitable media. Cells are treated with Tellimoside at various concentrations for 24-72 hours. Cell viability is assessed using MTT or similar assays. Cytokine levels are measured by ELISA. ROS levels are measured using DCFH-DA. The compound is typically dissolved in DMSO and diluted in culture media.
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| Animal Protocol |
In vivo studies for Tellimoside would be conducted in appropriate animal models of oxidative stress, inflammation, or cancer. The compound would be administered via oral gavage or intraperitoneal injection. However, specific published protocols for this compound are not available.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for Tellimoside are not reported. As a flavonoid glycoside, it is expected to have limited oral bioavailability. Pharmacokinetic studies would be required to determine absorption and metabolism.
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| Toxicity/Toxicokinetics |
As a flavonoid compound, Tellimoside is generally considered to have a moderate safety profile. However, comprehensive toxicology studies have not been published. The compound should be handled with appropriate safety precautions.
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| References | |
| Additional Infomation |
Quercetin 3-O-(6''-galloyl)-β-D-glucopyranoside has been reported in Eugenia selloi, Triplaris cumingiana, and other organisms with available data.
Tellimoside is a galloylated flavonoid glycoside with antioxidant, anti-inflammatory, and anticancer properties. Molecular formula: C₂₈H₂₄O₁₆, molecular weight: 616.48. No clinical trials exist. For research use only. |
| Molecular Formula |
C28H24O16
|
|---|---|
| Molecular Weight |
616.481
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| Exact Mass |
616.106
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| CAS # |
56316-75-7
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| PubChem CID |
9830456
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| Appearance |
Light yellow to yellow solid powder
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| LogP |
1
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| Hydrogen Bond Donor Count |
10
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| Hydrogen Bond Acceptor Count |
16
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
44
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| Complexity |
1070
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| Defined Atom Stereocenter Count |
5
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| SMILES |
C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)COC(=O)C5=CC(=C(C(=C5)O)O)O)O)O)O)O)O
|
| InChi Key |
FMQQLXJREAGPHS-OAYLZIFXSA-N
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| InChi Code |
InChI=1S/C28H24O16/c29-11-6-14(32)19-17(7-11)42-25(9-1-2-12(30)13(31)3-9)26(22(19)37)44-28-24(39)23(38)21(36)18(43-28)8-41-27(40)10-4-15(33)20(35)16(34)5-10/h1-7,18,21,23-24,28-36,38-39H,8H2/t18-,21-,23+,24-,28+/m1/s1
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| Chemical Name |
[(2R,3S,4S,5R,6S)-6-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl 3,4,5-trihydroxybenzoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6221 mL | 8.1106 mL | 16.2211 mL | |
| 5 mM | 0.3244 mL | 1.6221 mL | 3.2442 mL | |
| 10 mM | 0.1622 mL | 0.8111 mL | 1.6221 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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