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| Other Sizes |
| Targets |
4-(Dimethylamino)phenol is not a therapeutic compound and does not have specific biological targets. It is a chemical reagent used in organic synthesis. In combination with sodium nitrite, it antagonizes experimental cyanide poisoning, suggesting some pharmacological activity as a cyanide antidote. However, its primary use is as a chemical intermediate.
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| ln Vitro |
In vitro, 4-(Dimethylamino)phenol increases extracellular lactate dehydrogenase (LDH) but does not significantly affect gluconeogenesis. It cannot decrease ATP content until the membrane becomes permeable to LDH. These observations suggest effects on cell membrane integrity and cellular metabolism, but the compound is not used as a therapeutic agent.
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| ln Vivo |
4-(Dimethylamino)phenol is used in combination with sodium nitrite to antagonize experimental cyanide poisoning. This suggests some in vivo activity as a cyanide antidote. However, the compound is primarily a chemical reagent and intermediate, and specific in vivo protocols for therapeutic use are not detailed.
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| Enzyme Assay |
No specific biochemical assay protocols for 4-(Dimethylamino)phenol are detailed for therapeutic research. The compound is characterized by standard analytical chemistry methods. It has a molecular formula of C₈H₁₁NO and a molecular weight of 137.18 g/mol.
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| Cell Assay |
4-(Dimethylamino)phenol is not typically used in cellular assays as a therapeutic compound. It is a chemical reagent and intermediate. The compound has a molecular formula of C₈H₁₁NO and a molecular weight of 137.18 g/mol and should be stored at -20°C.
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| Animal Protocol |
In vivo studies for 4-(Dimethylamino)phenol as a cyanide antidote would be conducted in appropriate animal models of cyanide poisoning. The compound would be administered in combination with sodium nitrite. However, specific published protocols are not detailed.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 4-(Dimethylamino)phenol are not reported. The compound has a molecular formula of C₈H₁₁NO and a molecular weight of 137.18 g/mol.
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| Toxicity/Toxicokinetics |
4-(Dimethylamino)phenol should be handled with appropriate safety precautions. It may cause irritation to skin, eyes, and respiratory tract. Standard laboratory safety practices should be followed, including the use of gloves, eye protection, and proper ventilation.
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| References |
[1]. Szinicz LL, et al. Effects of 4-dimethylaminophenol in rat kidneys, isolated rat kidney tubules and hepatocytes. Xenobiotica. 1980;10(7-8):611-620.
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| Additional Infomation |
4-Dimethylaminophenol is a tertiary amine compound and also a dialkyl aromatic amine.
4-(Dimethylamino)phenol is a chemical reagent used in organic synthesis, dye preparation, and as a pharmaceutical intermediate. Molecular formula: C₈H₁₁NO, molecular weight: 137.18. No clinical therapeutic approvals exist. For research use only as a chemical reagent. |
| Molecular Formula |
C8H11NO
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|---|---|
| Molecular Weight |
137.18
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| Exact Mass |
137.084
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| CAS # |
619-60-3
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| Related CAS # |
5882-48-4 (hydrochloride);6626-08-0 (oxalate[1:1])
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| PubChem CID |
22174
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| Appearance |
Light brown to brown solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
259.7±23.0 °C at 760 mmHg
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| Melting Point |
74-76ºC
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| Flash Point |
135.6±21.3 °C
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| Vapour Pressure |
0.0±0.5 mmHg at 25°C
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| Index of Refraction |
1.590
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| LogP |
1.5
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
10
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| Complexity |
95.4
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CN(C)C1=CC=C(C=C1)O
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| InChi Key |
JVVRCYWZTJLJSG-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C8H11NO/c1-9(2)7-3-5-8(10)6-4-7/h3-6,10H,1-2H3
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| Chemical Name |
4-(dimethylamino)phenol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (728.97 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.2897 mL | 36.4485 mL | 72.8969 mL | |
| 5 mM | 1.4579 mL | 7.2897 mL | 14.5794 mL | |
| 10 mM | 0.7290 mL | 3.6448 mL | 7.2897 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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