| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| Other Sizes |
| Targets |
Zincon sodium targets metal ions, particularly zinc (Zn²⁺), copper (Cu²⁺), and cobalt (Co²⁺), through chelation. It acts as a multidentate ligand, binding to metal ions through multiple donor atoms. The compound does not have biological targets but is a chemical reagent used for analytical determination of metal ions in biological and environmental samples.
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|---|---|
| ln Vitro |
In vitro, Zincon sodium is used as a colorimetric reagent for detecting zinc and copper ions in aqueous solutions. It forms colored complexes with metal ions, allowing for quantitative determination by spectrophotometry. The compound is soluble in ethanol and alkaline solutions, slightly soluble in water, and insoluble in other organic solvents. It decomposes rapidly in acidic media.
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| ln Vivo |
Zincon sodium is not a therapeutic compound and has no in vivo biological activity. It is used as an analytical reagent in research laboratories. It may be used in ex vivo studies to determine metal ion concentrations in biological samples such as serum, tissues, or metalloprotein preparations.
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| Enzyme Assay |
The metal ion detection assay using Zincon sodium is performed by mixing the reagent with a sample containing metal ions in an aqueous solution at appropriate pH. The formation of a colored complex (e.g., blue with zinc) is measured spectrophotometrically. The concentration of metal ions is determined by comparing the absorbance to a standard curve. The compound has a molecular formula of C₂₀H₁₅N₄NaO₆S and a molecular weight of 462.41 g/mol (or 480.43 for monohydrate).
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| Cell Assay |
Zincon sodium is not used in cell-based assays as a therapeutic compound. It may be used in biochemical assays to measure metal ion concentrations in cell lysates or culture media. The compound is typically prepared as a solution in aqueous alkali or ethanol and added to samples for colorimetric detection. It is insoluble in water and should be dissolved in alkaline solution before use.
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| Animal Protocol |
Zincon sodium is not used in animal studies as it is an analytical reagent rather than a therapeutic compound. It may be used to measure metal ion concentrations in tissues or biological fluids harvested from animals in ex vivo analyses.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for Zincon sodium are not applicable as it is not a therapeutic compound. The compound has a molecular formula of C₂₀H₁₅N₄NaO₆S and a molecular weight of 462.41 g/mol (monohydrate: 480.43). It is soluble in ethanol and aqueous alkali, slightly soluble in water, and insoluble in other organic solvents.
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| Toxicity/Toxicokinetics |
Zincon sodium is a chemical reagent and should be handled with appropriate safety precautions. It is not intended for human consumption. The compound may cause irritation to skin, eyes, and respiratory tract. Standard laboratory safety practices should be followed, including the use of gloves, eye protection, and proper ventilation. Material safety data sheets should be consulted for detailed safety information.
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| References | |
| Additional Infomation |
Zincon sodium is a colorimetric reagent for detecting zinc, copper, and cobalt ions in aqueous solutions and metalloproteins. Molecular formula: C₂₀H₁₅N₄NaO₆S, molecular weight: 462.41. No clinical applications exist. For research use only as an analytical reagent.
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| Molecular Formula |
C20H16N4O6S
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|---|---|
| Molecular Weight |
440.4292
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| Exact Mass |
462.06
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| CAS # |
62625-22-3
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| PubChem CID |
135472945
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| Appearance |
Dark purple to black solid powder
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| Density |
1.5±0.1 g/cm3
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| Melting Point |
250-260 °C (dec.)
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| Index of Refraction |
1.682
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| LogP |
3.16
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
9
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
32
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| Complexity |
781
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1=CC=C(C=C1)/C(=N\NC2=C(C=CC(=C2)S(=O)(=O)[O-])O)/N=NC3=CC=CC=C3C(=O)O.[Na+]
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| InChi Key |
XBGLXASXFRESIN-JGXOCYJHSA-M
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| InChi Code |
InChI=1S/C20H16N4O6S.Na/c25-18-11-10-14(31(28,29)30)12-17(18)22-24-19(13-6-2-1-3-7-13)23-21-16-9-5-4-8-15(16)20(26)27;/h1-12,22,25H,(H,26,27)(H,28,29,30);/q;+1/p-1/b23-21?,24-19+;
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| Chemical Name |
sodium;3-[(2E)-2-[[(2-carboxyphenyl)diazenyl]-phenylmethylidene]hydrazinyl]-4-hydroxybenzenesulfonate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2705 mL | 11.3525 mL | 22.7051 mL | |
| 5 mM | 0.4541 mL | 2.2705 mL | 4.5410 mL | |
| 10 mM | 0.2271 mL | 1.1353 mL | 2.2705 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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