| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
The specific molecular targets of Corysamine chloride are not well characterized in the available literature. As an isoquinoline alkaloid, it may interact with various cellular targets involved in neuronal signaling. Further studies are needed to identify its primary mechanism of action and specific receptor or enzyme targets. The compound is primarily used as a research tool for studying alkaloid chemistry and natural product pharmacology.
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| ln Vitro |
Specific in vitro activity data for Corysamine chloride are not reported in the available literature. As a neuronal signaling compound, it may have activity in neuronal cell-based assays. However, specific IC50 values or detailed mechanistic data are not available. The compound is primarily used as a research chemical and reference standard for alkaloid studies.
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| ln Vivo |
Specific in vivo data for Corysamine chloride are not reported in the available literature. As a research compound, it has not been described in animal model studies. Further studies are needed to evaluate its in vivo efficacy and pharmacological properties. The compound is for research use only and not for human therapeutic use.
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| Enzyme Assay |
No specific biochemical assay protocols for Corysamine chloride are documented in the available literature. As an alkaloid compound, standard analytical characterization includes HPLC for purity assessment and NMR/MS for structural confirmation. If studying its biological activity, standard cell-based assays for neuronal signaling would be employed depending on the specific research question.
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| Cell Assay |
For cellular studies, Corysamine chloride would typically be dissolved in DMSO, chloroform, dichloromethane, ethyl acetate, or acetone and diluted in culture media for treatment of neuronal cell lines. Cells are cultured in appropriate media at 37°C in 5% CO₂. Cell viability and signaling pathway activation would be assessed using standard assays. The compound has a molecular formula of C₂₀H₁₆ClNO₄ and a molecular weight of 369.80 g/mol.
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| Animal Protocol |
Specific in vivo protocols for Corysamine chloride are not documented in the available literature. If used in animal studies, standard protocols for neuronal signaling compounds would be employed, with administration via intraperitoneal injection or oral gavage. However, no specific published studies are available.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for Corysamine chloride are not reported. The compound has a molecular formula of C₂₀H₁₆ClNO₄ and a molecular weight of 369.80 g/mol. It is soluble in chloroform, dichloromethane, ethyl acetate, DMSO, and acetone. The compound should be stored desiccated at -20°C. Pharmacokinetic studies would be required to determine absorption, distribution, metabolism, and excretion parameters.
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| Toxicity/Toxicokinetics |
Toxicological data for Corysamine chloride are not reported. As a research compound, comprehensive toxicology studies have not been published. The compound should be handled with appropriate safety precautions in laboratory settings. It is for research use only and not for human consumption.
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| References | |
| Additional Infomation |
Corysamine chloride is an alkaloid derived from Stylophorum lasiocarpum with molecular formula C₂₀H₁₆ClNO₄ and molecular weight 369.80. It belongs to neuronal signaling compounds. No clinical trials or regulatory approvals exist. For research use only.
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| Molecular Formula |
C20H16CLNO4
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|---|---|
| Molecular Weight |
369.798344612122
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| Exact Mass |
369.076
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| CAS # |
11028-77-6
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| PubChem CID |
15625376
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| Appearance |
Typically exists as solid at room temperature
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
26
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| Complexity |
530
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CC1=C2C=CC3=C(C2=C[N+]4=C1C5=CC6=C(C=C5CC4)OCO6)OCO3.[Cl-]
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| InChi Key |
WMUNRKMYZOSRSH-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C20H16NO4.ClH/c1-11-13-2-3-16-20(25-10-22-16)15(13)8-21-5-4-12-6-17-18(24-9-23-17)7-14(12)19(11)21;/h2-3,6-8H,4-5,9-10H2,1H3;1H/q+1;/p-1
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| Chemical Name |
24-methyl-5,7,17,19-tetraoxa-13-azoniahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(13),2,4(8),9,14,16(20),21,23-octaene;chloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7042 mL | 13.5208 mL | 27.0416 mL | |
| 5 mM | 0.5408 mL | 2.7042 mL | 5.4083 mL | |
| 10 mM | 0.2704 mL | 1.3521 mL | 2.7042 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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