| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 500mg |
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| 1g | |||
| Other Sizes |
| Targets |
The specific molecular targets of this natural product have not been fully characterized. As a caffeic acid-containing spermidine derivative, it likely interacts with pathways related to oxidative stress response, possibly through modulation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and reactive oxygen species scavenging.
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|---|---|
| ln Vitro |
Limited in vitro data is available. As a phenolic compound from Lycium ruthenicum, it is expected to exhibit antioxidant activity, potentially through the ability of its caffeoyl and dihydrocaffeoyl moieties to donate hydrogen atoms and neutralize free radicals. It may also influence cellular signaling pathways related to inflammation and cell survival.
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| ln Vivo |
In vivo data for this specific compound is limited. However, as a component of Lycium ruthenicum extracts, it may contribute to the observed health benefits of black wolfberry consumption, including antioxidant, anti-inflammatory, and potential neuroprotective effects. Detailed animal efficacy studies on the isolated compound are currently lacking.
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| Enzyme Assay |
The compound is a natural product and is typically isolated from plant sources rather than being used in standardized enzyme assays. For chemical characterization, HPLC coupled with UV/Vis or MS detection is used to confirm identity and purity. Quality control assays are primarily analytical chemistry-based.
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| Cell Assay |
Cell-based assays for this compound are not standard. Researchers investigating its activity might use general antioxidant assays such as DPPH radical scavenging or ABTS assays. For cell-based experiments, typical protocols would involve pre-treating cultured cells with the compound (1-100 uM) followed by oxidative stress induction to assess protective effects.
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| Animal Protocol |
Animal studies on the isolated N1-Dihydrocaffeoyl, N10-caffeoyl spermidine have not been reported. If conducted, typical protocols might involve administration of the compound (oral or intraperitoneal) in rodent models of oxidative stress or inflammation, followed by analysis of tissue antioxidant enzyme activities and inflammatory markers.
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| ADME/Pharmacokinetics |
No pharmacokinetic data is available for this compound. As a natural product isolated from Lycium ruthenicum, its absorption, distribution, metabolism, and excretion would be expected to be similar to other dietary polyphenols, likely with low oral bioavailability and extensive phase II metabolism.
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| Toxicity/Toxicokinetics |
No direct toxicity data is available for this specific compound. As a natural product from Lycium ruthenicum, a traditionally consumed food, it is expected to have a low toxicity profile at typical dietary intake levels. However, isolated compound safety data is not available, and appropriate precautions should be taken.
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| References | |
| Additional Infomation |
This compound is a natural product that can be extracted from Lycium ruthenicum Murr. (black wolfberry) and is available for research use. It is supplied as a solid (typically off-white to light yellow) with purity ≥98%. It serves as a tool for investigating the biological activities of caffeoyl-spermidine conjugates, including potential antioxidant, anti-inflammatory, and neuroprotective properties.
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| Molecular Formula |
C25H33N3O6
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|---|---|
| Molecular Weight |
471.546026945114
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| Exact Mass |
471.236
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| CAS # |
1698873-84-5
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| PubChem CID |
164898522
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| Appearance |
Typically exists as solid at room temperature
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| LogP |
2.1
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| Hydrogen Bond Donor Count |
7
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
14
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| Heavy Atom Count |
34
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| Complexity |
632
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1=CC(=C(C=C1CCC(=O)NCCCCNCCCNC(=O)/C=C/C2=CC(=C(C=C2)O)O)O)O
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| InChi Key |
UKDQTQBQRCLXJK-YRNVUSSQSA-N
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| InChi Code |
InChI=1S/C25H33N3O6/c29-20-8-4-18(16-22(20)31)6-10-24(33)27-14-2-1-12-26-13-3-15-28-25(34)11-7-19-5-9-21(30)23(32)17-19/h4-5,7-9,11,16-17,26,29-32H,1-3,6,10,12-15H2,(H,27,33)(H,28,34)/b11-7+
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| Chemical Name |
3-(3,4-dihydroxyphenyl)-N-[4-[3-[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]propylamino]butyl]propanamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1207 mL | 10.6033 mL | 21.2067 mL | |
| 5 mM | 0.4241 mL | 2.1207 mL | 4.2413 mL | |
| 10 mM | 0.2121 mL | 1.0603 mL | 2.1207 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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