| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 1g |
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| Other Sizes |
| Targets |
4,5-Dichlorocatechol does not have a specific biological target as a therapeutic agent. It is a chemical intermediate used in the synthesis of dioxin derivatives. The compound is a chlorinated catechol and may have endocrine-disrupting potential.
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|---|---|
| ln Vitro |
4,5-Dichlorocatechol is a chemical intermediate and does not possess intrinsic biological activity. It is used as a research chemical for organic synthesis. No specific in vitro biological activity data are available for this compound.
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| ln Vivo |
The compound is not intended for in vivo use as a therapeutic agent. It is a chemical intermediate used in organic synthesis. No pharmacological in vivo studies have been reported.
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| Enzyme Assay |
4,5-Dichlorocatechol is not used in enzyme/receptor binding assays. It is a chemical intermediate used in organic synthesis.
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| Cell Assay |
No cell-based assay protocols are applicable for this compound. It is a chemical intermediate used for synthesis purposes.
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| Animal Protocol |
No in vivo animal experiment protocols are applicable for 4,5-Dichlorocatechol as a test compound. As a chemical intermediate, it is not administered to animals for therapeutic or pharmacological studies.
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| ADME/Pharmacokinetics |
Pharmacokinetic data are not applicable for 4,5-Dichlorocatechol as it is a chemical intermediate, not a pharmaceutical agent.
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| Toxicity/Toxicokinetics |
4,5-Dichlorocatechol may have endocrine-disrupting potential. The compound is a chlorinated catechol and is classified as a Category IV endocrine disruptor. Standard laboratory safety precautions should be followed when handling the compound.
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| References |
[1]. T Potrawfke , et al. Chlorocatechols Substituted at Positions 4 and 5 Are Substrates of the Broad-Spectrum Chlorocatechol 1,2-dioxygenase of Pseudomonas Chlororaphis RW71. J Bacteriol. 2001 Feb;183(3):997-1011.
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| Additional Infomation |
4,5-Dichlorocatechol is a chlorinated derivative of catechol used as an intermediate in the preparation of dioxin derivatives. It has a molecular formula of C₆H₄Cl₂O₂ and a molecular weight of 179.00 g/mol. The compound is a research chemical for organic synthesis. It is not a drug and has no clinical applications.
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| Molecular Formula |
C6H4CL2O2
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|---|---|
| Molecular Weight |
179.00
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| Exact Mass |
177.958
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| CAS # |
3428-24-8
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| PubChem CID |
18909
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.6±0.1 g/cm3
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| Boiling Point |
302.2±37.0 °C at 760 mmHg
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| Melting Point |
110-115ºC(lit.)
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| Flash Point |
136.6±26.5 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
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| Index of Refraction |
1.642
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| LogP |
3.29
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
10
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| Complexity |
106
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1=C(C(=CC(=C1O)O)Cl)Cl
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| InChi Key |
ACCHWUWBKYGKNM-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H4Cl2O2/c7-3-1-5(9)6(10)2-4(3)8/h1-2,9-10H
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| Chemical Name |
4,5-dichlorobenzene-1,2-diol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.5866 mL | 27.9330 mL | 55.8659 mL | |
| 5 mM | 1.1173 mL | 5.5866 mL | 11.1732 mL | |
| 10 mM | 0.5587 mL | 2.7933 mL | 5.5866 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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