| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| Other Sizes |
| Targets |
The molecular targets of 8-O-4,8-O-4-Dehydrotriferulic acid are not well characterized. As a dehydrotriferulic acid, it may exhibit antioxidant activity through free radical scavenging. Its presence in corn bran insoluble fiber suggests it may have effects on gut health and metabolism. However, specific molecular targets have not been identified.
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|---|---|
| ln Vitro |
In vitro studies of 8-O-4,8-O-4-Dehydrotriferulic acid are limited. As a dehydrotriferulic acid, it may exhibit antioxidant activity. It is isolated from saponified corn bran insoluble fiber for research purposes. However, specific potency data such as IC₅₀ values are not detailed in the available literature.
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| ln Vivo |
Specific in vivo activity data for 8-O-4,8-O-4-Dehydrotriferulic acid are not available in the consulted sources. As a compound from corn bran fiber, it may have potential effects on gut health and metabolism. However, no systematic in vivo studies have been reported.
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| Enzyme Assay |
Typical in vitro assays for 8-O-4,8-O-4-Dehydrotriferulic acid include antioxidant assays such as DPPH and ABTS radical scavenging. The compound can also be analyzed by HPLC and NMR for structural characterization.
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| Cell Assay |
No specific cell-based assay protocols are available for 8-O-4,8-O-4-Dehydrotriferulic acid. For potential biological activity, standard cell viability or antioxidant assays could be employed, but none have been reported.
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| Animal Protocol |
In vivo animal experiments for 8-O-4,8-O-4-Dehydrotriferulic acid are not detailed in the available literature. For studying dietary fiber components, animal models of gut health or metabolism could be employed, but no specific protocols have been established.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 8-O-4,8-O-4-Dehydrotriferulic acid are not available. As a large, polar compound with a molecular weight of 578.52 g/mol, it would be expected to have poor oral bioavailability. Detailed ADME parameters have not been characterized.
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| Toxicity/Toxicokinetics |
No toxicological data are available for 8-O-4,8-O-4-Dehydrotriferulic acid in the consulted sources. As a compound from corn bran fiber, it is generally considered to have low toxicity. Standard laboratory safety precautions should be followed.
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| References | |
| Additional Infomation |
Reports indicate that Fatsia japonica and Centella asiatica contain (E)-3-[4-[[(Z)-1-carboxy-2-[4-[[(Z)-1-carboxy-2-(3-methoxy-4-hydroxyphenyl)vinyl]oxy]-3-methoxyphenyl]vinyl]oxy]-3-methoxyphenyl]acrylic acid, and related data have been reported.
8-O-4,8-O-4-Dehydrotriferulic acid is a dehydrotriferulic acid isolated from saponified corn bran insoluble fiber. It is a trimer of ferulic acid linked through 8-O-4 couplings. The compound is used in research on plant cell wall structure and dietary fiber. It is a research compound and is not approved for any clinical indication. |
| Molecular Formula |
C30H26O12
|
|---|---|
| Molecular Weight |
578.520249843597
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| Exact Mass |
578.142
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| CAS # |
848649-28-5
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| PubChem CID |
21580474
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| Appearance |
Typically exists as solid at room temperature
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| LogP |
4.8
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| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
12
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| Rotatable Bond Count |
13
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| Heavy Atom Count |
42
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| Complexity |
1020
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| Defined Atom Stereocenter Count |
0
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| SMILES |
COC1=C(C=CC(=C1)/C=C/C(=O)O)O/C(=C\C2=CC(=C(C=C2)O/C(=C\C3=CC(=C(C=C3)O)OC)/C(=O)O)OC)/C(=O)O
|
| InChi Key |
UWXGIJKBCAIMFK-XVAVVJJYSA-N
|
| InChi Code |
InChI=1S/C30H26O12/c1-38-23-13-18(4-8-20(23)31)15-26(29(34)35)42-22-10-6-19(14-25(22)40-3)16-27(30(36)37)41-21-9-5-17(7-11-28(32)33)12-24(21)39-2/h4-16,31H,1-3H3,(H,32,33)(H,34,35)(H,36,37)/b11-7+,26-15-,27-16-
|
| Chemical Name |
(Z)-2-[4-[(Z)-2-carboxy-2-[4-[(E)-2-carboxyethenyl]-2-methoxyphenoxy]ethenyl]-2-methoxyphenoxy]-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7285 mL | 8.6427 mL | 17.2855 mL | |
| 5 mM | 0.3457 mL | 1.7285 mL | 3.4571 mL | |
| 10 mM | 0.1729 mL | 0.8643 mL | 1.7285 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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