| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ln Vitro |
Phytic acid (0.05%–0.4% (w/w), 5 min), hexalithium, and sodium chloride all showed significant synergistic bactericidal effects against both unadapted and acid-adapted Escherichia coli O157:H7 strains [2]. Phytic acid (1–5 mM, 2–3 h) and hexalithium reduced the integrity of Caco-2 cell monolayers by modulating the localization of tight junction proteins and downregulating their expression levels without causing cytotoxicity to Caco-2 cells [3]. Phytic acid (48–72 h) and hexalithium completely protected cells from cytotoxicity induced by the C-terminal fragment of amyloid precursor protein by attenuating intracellular levels of calcium, hydrogen peroxide, superoxide, and Aβ oligomers and moderately upregulating the expression of beclin-1 in MC65 cells [5]. Phytic acid (≥1 mM) and hexalithium stimulated suicide death in human erythrocytes [6].
|
|---|---|
| ln Vivo |
Phytic acid (2%, feed, ad libitum, for 21 days) hexalithium salts reduced growth performance in pigs, partly due to decreased sodium absorption in the small intestine [4]. Phytic acid (2%, drinking water, for 6 months) hexalithium salts improved Alzheimer's pathology (AP180, beclin-1, LC3B, sirtuin 1) in Tg2576 mice [5]. Phytic acid (20 mg/kg, intraperitoneal injection, pretreatment 5 hours before coronary artery occlusion) hexalithium salts inhibited hydroxyl radical generation induced by myocardial ischemia in rats [7]. Phytic acid (100 mg/kg/day, gavage, 5 days a week, for 8 weeks) hexalithium salts had a protective effect against carbon tetrachloride-induced liver fibrosis in mice [8]. Phytic acid (4% rodent feed, diet, for 30 days) hexalithium salts reduced lipogenesis enzyme activity in diabetic rats [9]. Phytic acid (1-2 g/100 g, soluble in water, 13 weeks) hexalithium has anticancer effects on rats with colon cancer, reducing ACF by 36% (1 g/100 g phytic acid) and 42% (2 g/100 g phytic acid) respectively [10].
|
| Cell Assay |
Cell viability assay [3]
Cell Types: Caco-2 Tested Concentrations: 1, 2, 2.5, 3.5, 5 mM Incubation Duration: 3 hours Experimental Results: In the experiment, when the IP6 concentration was 1-5 mM, more than 90% of the cells were viable. |
| Animal Protocol |
Animal/Disease Models:Piglets with an initial weight of 7.40 kg [4]
Doses: 2% (phytic acid/feed) Route of Administration: Feed, 21 days Experimental Results: No effect on plasma glucose and sodium concentrations. Reduced total potential difference and total short-circuit current. No effect on plasma glucose and sodium concentrations. No effect on SGLT1 protein expression. |
| References |
|
| Molecular Formula |
C6H12LI6O24P6
|
|---|---|
| Molecular Weight |
695.63
|
| Appearance |
Typically exists as solids at room temperature
|
| SMILES |
O=P(O)(O[Li])O[C@H]1[C@@H]([C@H]([C@@H]([C@H]([C@H]1OP(O)(O[Li])=O)OP(O)([Li][O])=O)OP(O)(O[Li])=O)OP(O)(O[Li])=O)OP(O)([Li][O])=O
|
| Synonyms |
Inositol hexaphosphate hexalithium; SNF472 hexalithium
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.4375 mL | 7.1877 mL | 14.3755 mL | |
| 5 mM | 0.2875 mL | 1.4375 mL | 2.8751 mL | |
| 10 mM | 0.1438 mL | 0.7188 mL | 1.4375 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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