| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ln Vitro |
ABBV-011 (0.01-100000 pM; 96 hours) can efficiently and selectively kill HEK293T cells overexpressing human SEZ6, with an IC50 of 75 pM after 96 hours of incubation [1]. ABBV-011 (1-100000 pM; 96 hours) has target-specific cytotoxicity against parental NCI-H69 small cell lung cancer cells, with an IC50 of 106 pM after 96 hours of incubation, but has no activity against SEZ6 knockout NCI-H69 cells [1].
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|---|---|
| ln Vivo |
ABBV-011 (0.5–8 mg/kg; intraperitoneal injection; single dose) induced dose-dependent, SEZ6-targeted tumor regression in a SEZ6-positive small cell lung cancer PDX model [1].
|
| Cell Assay |
Cytotoxicity assay [1]
Cell Types: Parental NCI-H69 small cell lung cancer cells (endogenous SEZ6 expression); SEZ6 knockout NCI-H69 small cell lung cancer cells Tested Concentrations: 1-100,000 pM Incubation Duration: 96 hours Experimental Results: It showed strong activity in parental NCI-H69 cells, with an IC50 of 106 pM. In SEZ6 knockout NCI-H69 cells, no activity was shown even at the highest test concentration. |
| Animal Protocol |
Animal/Disease Models:NOD/SCID mice carrying SCLC P PDX tumor cells (female, 5 to 10 weeks old) [1]
Doses: 0.5 mg/kg; 1 mg/kg; 2 mg/kg; 4 mg/kg; 8 mg/kg Route of Administration: Intraperitoneal injection; single dose Experimental Results: Sustained tumor regression was induced in SEZ6-positive LU64, LU95, LU129, and LU149 PDX models. Even at a dose of 8 mg/kg, it had only a minimal effect on tumor growth in the SEZ6-negative LU505 PDX model. |
| References |
| Appearance |
Typically exists as solids at room temperature
|
|---|---|
| SMILES |
[ABBV-011]
|
| Synonyms |
SC-011
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| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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