| Size | Price | Stock | Qty |
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| 5g |
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| 10g |
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| 25g |
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| 50g |
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| 100g |
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| Other Sizes |
| Targets |
This compound does not have a defined biological target. It is a chemical intermediate and industrial chemical. Its mechanism of action is chemical; as a diester, it can be hydrolyzed under basic or acidic conditions or by esterase enzymes to release palmitic acid and ethylene glycol. In biological contexts, the ester may be hydrolyzed by lipases, but the parent compound is not designed to interact with specific receptors or enzymes.
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| ln Vitro |
In vitro, 1,2-Dipalmitoyl ethylene glycol is not typically evaluated for biological activity, as it is an industrial intermediate. It is used as a component in in vitro studies of polymer degradation or as a model compound for studying lipid metabolism. It may be added to cell culture media to study the effects of fatty acid esters on cell viability or function, but this is not its primary application.
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| ln Vivo |
The compound is not used in vivo for therapeutic purposes. It is an industrial chemical used in manufacturing. It is not a drug candidate and is not administered to animals for therapeutic evaluation. It may be used in toxicological studies as part of safety assessments for industrial chemicals.
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| Enzyme Assay |
Non-cell-based experiments for 1,2-Dipalmitoyl ethylene glycol are primarily analytical. A typical GC‑MS method for its analysis uses a DB‑5MS column (30 m × 0.25 mm, 0.25 um) with a temperature program: initial 100degC for 1 min, ramp to 320degC at 15degC/min. The compound elutes at a high temperature due to its high molecular weight (538.89) and long alkyl chains. For HPLC, a C18 reverse‑phase column with a mobile phase of isopropanol/acetonitrile/water and an evaporative light scattering detector (ELSD) or charged aerosol detector (CAD) can be used. The compound is a waxy solid at room temperature with a melting point of approximately 69-71degC. It is stored at 2-8degC (refrigerated), sealed, and protected from light.
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| Cell Assay |
Cell-based assays are not typically performed for this compound. It is an industrial intermediate and is not intended for use in cell culture. Any cell-based evaluations would be performed on the final products (e.g., polymer degradation products) and not on the parent compound.
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| Animal Protocol |
In vivo animal experiments are not conducted for this compound as a drug candidate. It may be used in toxicological safety assessment studies. A standard 28‑day repeated‑dose oral toxicity study in rats (OECD TG 407) might be conducted. The compound would be administered by oral gavage at doses of 100, 500, and 1000 mg/kg/day for 28 days. Endpoints include clinical observations, body weight, food consumption, hematology, serum chemistry, organ weights, and histopathology. Given that the compound is a lipid-like diester, oral absorption is likely low, and the primary site of action would be the gastrointestinal tract.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 1,2-Dipalmitoyl ethylene glycol are limited. As a large, non‑polar diester (molecular weight 538.89, log P estimated >7), it is virtually insoluble in water and will have very low oral bioavailability. If absorbed, it would likely be hydrolyzed by esterases in the gut and liver to palmitic acid and ethylene glycol. Palmitic acid is a common dietary fatty acid and is metabolized via beta‑oxidation. Ethylene glycol is toxic, but the amounts released would be minimal. The compound is stored at 2-8degC in a sealed container.
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| Toxicity/Toxicokinetics |
The toxicity profile of 1,2-Dipalmitoyl ethylene glycol is expected to be low due to its large size and low bioavailability. However, its hydrolysis product, ethylene glycol, is toxic. As a research chemical, standard safety precautions apply: the compound may be harmful if swallowed, inhaled, or absorbed through the skin. It may cause skin and eye irritation. It should be handled in a well-ventilated area (fume hood) with appropriate PPE. The product is not for human or veterinary use.
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| Additional Infomation |
Additional information: The compound has a molecular formula of C34H₆₆O4 and a molecular weight of 538.89 g/mol. The CAS number is 624-03-3. It is also known as ethylene glycol dipalmitate and 16:0 diester of ethylene glycol. The compound is for research and industrial use only and is not intended for pharmaceutical applications.
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| Molecular Formula |
C34H66O4
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|---|---|
| Molecular Weight |
538.89
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| Exact Mass |
538.496
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| CAS # |
624-03-3
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| Related CAS # |
32628-06-1
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| PubChem CID |
69347
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| Appearance |
White to off-white solid powder
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| Hydrogen Bond Donor Count |
0
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| Rotatable Bond Count |
33
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| Heavy Atom Count |
38
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| Complexity |
447
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCC
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| InChi Key |
IKVCSHRLYCDSFD-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C34H66O4/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(35)37-31-32-38-34(36)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h3-32H2,1-2H3
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| Chemical Name |
2-hexadecanoyloxyethyl hexadecanoate
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| Synonyms |
Ethylene glycol dipalmitate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8557 mL | 9.2783 mL | 18.5567 mL | |
| 5 mM | 0.3711 mL | 1.8557 mL | 3.7113 mL | |
| 10 mM | 0.1856 mL | 0.9278 mL | 1.8557 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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