| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Cyclohexene can be rapidly absorbed through skin, eyes, or respiratory contact, or after ingestion. These hydrocarbons have low absorption rates in the gastrointestinal tract, and unless inhalation occurs, they do not cause significant systemic toxicity via this route. …Two male Holzmann rats were each given 0.1 mL (81.1 mg/kg body weight) of cyclohexene via gastric tube… 24-hour urine samples contained 2-cyclohexen-1-one (0.1% of the oral dose), but 2-cyclohexen-1-ol was not detected even after β-glucuronidase treatment. In an inhalation study, male F344/N rats were exposed to gaseous cyclohexene at a concentration of 600 ppm (2015 mg/m³) via nasal cavity for 60 minutes… During the exposure, the blood concentration of cyclohexene increased to 2 μg/g blood. Metabolism / Metabolites After incubation of *Aspergillus niger* with cyclohexene, three transformation products were isolated: 2-cyclohexen-1-one, (+)-2-cyclohexen-1-ol, and (+)-3-cyclohexen-1,2-cis-diol. Microsomal oxidase was detected in rabbit liver, which rapidly hydroxylates cyclohexene and several related aromatic compounds to their corresponding dihydroxy derivatives. Hydroxylation of the allyl nucleotide site of cyclohexene occurred in liver microsomes and the supernatant after centrifugation at 9000 g in both rat and rabbits. The formation of the product 2-cyclohexen-1-ol requires the NADPH generation system, is inhibited by CO, and is induced by phenobarbital. In rabbits, hydroxylation and conjugation reactions occur simultaneously, generating sulfur-containing metabolites. The hydroxylated and conjugated metabolites are excreted in the urine… |
|---|---|
| Toxicity/Toxicokinetics |
Non-Human Toxicity Values
Oral LD50 in rats: 2.4 mL (1946 mg)/kg; Oral LD50 in mice: >3.2 mL (2595 mg)/kg; Oral LD50 in guinea pigs: >20 mL (16220 mg)/kg Toxicity Data LC (rat) => 6,370 ppm/4H |
| References | |
| Additional Infomation |
Cyclohexene is a colorless liquid, insoluble in water, with a density less than water and a flash point of -7°C. Its vapor is heavier than air. Inhalation of high concentrations of cyclohexene may have an anesthetic effect. It can be used in the manufacture of other chemicals. Cyclohexene is a cycloalkene, consisting of cyclohexane molecules containing a double bond. It has been reported to be detected in black rats (Rattus rattus), rue (Tetradium ruticarpum), and Guiana tapirs (Tapirira guianensis), and relevant data are available.
|
| Molecular Formula |
C6H10
|
|---|---|
| Molecular Weight |
82.14
|
| Exact Mass |
82.078
|
| CAS # |
110-83-8
|
| Related CAS # |
25012-94-6
|
| PubChem CID |
8079
|
| Appearance |
Colorless liquid
|
| Density |
0.8±0.1 g/cm3
|
| Boiling Point |
85.6±7.0 °C at 760 mmHg
|
| Melting Point |
-154 °F (NIOSH, 2024)
; -103.5 °C
; -104 °C
; -154 °F
; -103.7 °C
; -154 °F
|
| Flash Point |
-12.2±0.0 °C
|
| Vapour Pressure |
77.0±0.1 mmHg at 25°C
|
| Index of Refraction |
1.459
|
| LogP |
2.89
|
| Hydrogen Bond Donor Count |
0
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
6
|
| Complexity |
45.1
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C1=CCCCC1
|
| InChi Key |
HGCIXCUEYOPUTN-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C6H10/c1-2-4-6-5-3-1/h1-2H,3-6H2
|
| Chemical Name |
cyclohexene
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 12.1743 mL | 60.8717 mL | 121.7434 mL | |
| 5 mM | 2.4349 mL | 12.1743 mL | 24.3487 mL | |
| 10 mM | 1.2174 mL | 6.0872 mL | 12.1743 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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