| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ln Vitro |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Studies involving the human use of drugs labeled with deuterium suggest that these compounds may offer some advantages when compared with their nondeuterated counterparts. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. Deutetrabenazine is the first deuterated drug to receive Food and Drug Administration approval. This deuterated form of the drug tetrabenazine is indicated for the treatment of chorea associated with Huntington's disease as well as tardive dyskinesia. Ongoing clinical trials suggest that a number of other deuterated compounds are being evaluated for the treatment of human diseases and not merely as research tools.[1] Treatment of LPS-stimulated microglia with 5, 10, and 20 μM Ribavirin (ICN-1229) induced a 43% (p<0.05), 53% (p<0.05), and 59% (p < 0.05) decrease in NO2 levels. Ribavirin (ICN-1229) (10 mM) did not significantly reduce cell surface area in non-stimulated cultures, but significantly reduced cell surface area in LPS-stimulated microglia (32%, p<0.05)[4]. Ribavirin (ICN-1229) was active against DENV with an EC50 of 3 μM in A549 cells, and the combination of CM-10-18 and Ribavirin (ICN-1229) was effective in reducing viral replication[5].
|
|||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ln Vivo |
ALT, AST activities and bilirubin levels were significantly decreased by JAT combined with interferon and Ribavirin (ICN-1229) administration (p<0.01). When JAT, interferon, or Ribavirin were used alone with CCl4, the liver appeared to exhibit some hepatoprotection against CCl4 as evidenced by the presence of normal hepatic cords, the absence of necrosis, and less fat infiltration. Groups treated with JAT, pegylated interferon, and Ribavirin (ICN-1229) alone or in combination showed decreased expression of TGF-β and Bax. In the interferon, Ribavirin (ICN-1229) and JAT triple treatment group, the expression level of p53 was significantly reduced[2]. Wistar rats treated with Ribavirin (ICN-1229) capsules (400 mg Ribavirin) showed a significant decrease in activin A and a significant increase in follistatin at serum and liver levels. Ribavirin (ICN-1229) exhibits strong antiviral activity only when it is used in combination with IFN-α or Peg-IFN-α[3]. Ribavirin (40 mg/kg, po) significantly enhanced the antiviral efficacy of CM-10-18 in mice. Ribavirin (ICN-1229) inhibits DENV infection in cultured cells, but single-agent treatment is ineffective in reducing viremia[5].
|
|||||||||||||||||||||||||||||||||||||
| References |
Physicochemical Properties
Solubility Data
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculator
Molarity Calculator allows you to calculate the mass, volume, and/or concentration required for a solution, as detailed below:
An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?
Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:
What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:
Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:
Note: Chemical formula is case sensitive: C12H18N3O4 c12h18n3o4
Instructions to calculate molar mass (molecular weight) of a chemical compound:
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Reconstitution Calculator allows you to calculate the volume of solvent required to reconstitute your vial.
In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)
Calculation results Working concentration： mg/mL； Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
Products are for research use only; We do not sell to patients 
|
