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| Other Sizes |
| Targets |
Not applicable. 2-Naphthalenemethanol is an aromatic alcohol and a synthetic intermediate, not a drug with a specific biological target. It is not known to have significant biological activity. Its primary uses are in analytical chemistry and organic synthesis. It may be used as a starting material for the synthesis of more complex molecules that have biological activity, but the parent alcohol is not itself a pharmacologically active agent. It has low water solubility and is used as a marker for CMC determination.
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| ln Vitro |
The “activity” of 2-Naphthalenemethanol is physical and analytical, not biological. It is used as a marker in the determination of critical micelle concentration (CMC) of anionic surfactants by capillary electrophoresis. The compound is added to a surfactant solution, and as surfactant micelles form, the partitioning of the naphthalenemethanol between the aqueous phase and the micellar phase changes its electrophoretic mobility. The CMC is determined from the change in mobility. No biological IC50/EC50 data is relevant. It has been used in the synthesis of acetate protected xylosides.
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| ln Vivo |
No specific in vivo data is available for 2-Naphthalenemethanol as a drug. It is not used as a therapeutic agent. It is a research chemical for analytical chemistry and organic synthesis. It is not intended for in vivo administration. Any in vivo studies would be related to toxicology or metabolism, but no such studies are reported in the available literature. It is not a drug candidate.
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| Enzyme Assay |
Standard protocol for using 2-Naphthalenemethanol as a CMC marker in capillary electrophoresis: Prepare solutions of the anionic surfactant (e.g., sodium dodecyl sulfate, SDS) at various concentrations (0-20 mM) in buffer (e.g., 20 mM phosphate, pH 7.0). Add a fixed concentration (e.g., 0.1-0.5 mM) of 2-Naphthalenemethanol as a marker. Inject the sample into a capillary electrophoresis system with UV detection (λ ~ 225-254 nm). Measure the migration time or electrophoretic mobility of the marker. Plot mobility vs. surfactant concentration. The CMC is the surfactant concentration at which the mobility begins to change. The compound is not used in biological assays.
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| Cell Assay |
Not applicable. 2-Naphthalenemethanol is not used in cell-based assays as a pharmacological agent. For cytotoxicity screening, mammalian cells (e.g., HEK293) are seeded in 96-well plates and treated with 2-naphthalenemethanol (1-500 uM) for 24-72 hours. Cell viability is measured by MTT or CellTiter-Glo assay. The IC50 for cytotoxicity is calculated. No specific data is provided. The compound may be used as a positive control for cytochrome P450 induction or as a substrate for metabolism studies, but no such data is provided.
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| Animal Protocol |
Not applicable. 2-Naphthalenemethanol is not administered to animals for efficacy studies. For toxicity testing, an acute oral toxicity test (OECD 423) could be performed in rats. Female SD rats are fasted overnight then administered a single oral gavage dose (e.g., 300, 1000, 2000 mg/kg). Animals are observed for 14 days for signs of toxicity. The LD50 is calculated. No data is provided. The compound is a combustible solid and should be handled away from heat and open flame. It may be an irritant. Standard laboratory safety precautions should be followed. No specific protocols are provided.
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| ADME/Pharmacokinetics |
Not applicable. 2-Naphthalenemethanol is a small, lipophilic molecule (MW 158.20, LogP ~2.5). It is absorbed if ingested, metabolized by the liver via oxidation of the alcohol to the carboxylic acid (2-naphthoic acid), followed by glucuronidation or conjugation with glycine. The metabolites are excreted in urine. However, no formal PK studies are reported. It is not a drug candidate. Storage: Sealed in dry conditions at room temperature. Protect from light.
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| Toxicity/Toxicokinetics |
2-Naphthalenemethanol is an irritant and is combustible. It may cause skin and eye irritation (H315, H319). It may cause respiratory irritation (H335). Highly flammable (H226). Avoid generation of dust. Use in a fume hood with appropriate PPE (gloves, lab coat, safety goggles). Keep away from heat, sparks, and open flames. In case of fire, use dry chemical, carbon dioxide, or alcohol-resistant foam. For research use only, not for human or veterinary consumption. Disposal should comply with local regulations for hazardous waste.
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| References | |
| Additional Infomation |
2-Naphthalenemethanol is a naphthyl methanol, meaning that one methyl hydrogen atom in the methanol molecule is replaced by a (2-naphthyl) group. It is a metabolite found in mice and also a metabolite of exogenous substances. (2-Naphthyl)ethanol is a metabolite discovered or produced in *Escherichia coli* (K12 strain, MG1655 strain).
2-Naphthalenemethanol (CAS: 1592-38-7) has a molecular formula of C11H10O and a molecular weight of 158.20. IUPAC name: naphthalen-2-ylmethanol. Synonyms: 2-Hydroxymethylnaphthalene, 2-Naphthylmethanol. Appearance: White to light yellow crystalline powder. Melting point: 79-81degC. Purity: Typically >98% (GC). Solubility: Slightly soluble in water, soluble in organic solvents (chloroform, acetonitrile). Storage: Room temperature, sealed in dry conditions. For research use only. |
| Molecular Formula |
C11H10O
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|---|---|
| Molecular Weight |
158.20
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| Exact Mass |
158.073
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| CAS # |
1592-38-7
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| PubChem CID |
74128
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
319.6±11.0 °C at 760 mmHg
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| Melting Point |
79-81 °C(lit.)
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| Flash Point |
154.0±15.1 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
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| Index of Refraction |
1.657
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| LogP |
2.27
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
12
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| Complexity |
144
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
C1C2C(=CC=CC=2)C=CC=1CO
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| InChi Key |
MFGWMAAZYZSWMY-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11H10O/c12-8-9-5-6-10-3-1-2-4-11(10)7-9/h1-7,12H,8H2
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| Chemical Name |
naphthalen-2-ylmethanol
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| Synonyms |
2-Naphthalenemethanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.3211 mL | 31.6056 mL | 63.2111 mL | |
| 5 mM | 1.2642 mL | 6.3211 mL | 12.6422 mL | |
| 10 mM | 0.6321 mL | 3.1606 mL | 6.3211 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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