| Size | Price | |
|---|---|---|
| 25mg | ||
| 50mg | ||
| 100mg | ||
| 250mg | ||
| 500mg |
Purity: ≥98%
Prexasertib lactate hydrate (also known as LY2606368 lactate hydrate), the hydrated and lactate salt form of Prexasertib, is an ATP-competitive inhibitor of the CHK1 (checkpoint kinase 1) protein kinase (IC50 <1 nM and 8 nM for CHK1 and CHK2, respectively) with anticancer activity.
| References |
:Mol Cancer Ther.2015 Sep;14(9):2004-13;Am J Cancer Res.2017 Mar 1;7(3):473-483.
|
|---|
| Molecular Formula |
C21H27N7O6
|
|---|---|
| Molecular Weight |
473.49
|
| CAS # |
2100300-72-7
|
| Related CAS # |
1234015-54-3 (2HCl);1234015-55-4 (mesylate);1234015-52-1;1234015-57-6 (mesylate hydrate); 2100300-72-7 (lactate hydrate);
|
| SMILES |
N#CC1=NC=C(NC2=NNC(C3=C(OC)C=CC=C3OCCCN)=C2)N=C1.OC(C)C(O)=O.[H]O[H]
|
| InChi Key |
SQQVRJAAUOKBIG-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C18H19N7O2.C3H6O3.H2O/c1-26-14-4-2-5-15(27-7-3-6-19)18(14)13-8-16(25-24-13)23-17-11-21-12(9-20)10-22-171-2(4)3(5)6/h2,4-5,8,10-11H,3,6-7,19H2,1H3,(H2,22,23,24,25)2,4H,1H3,(H,5,6)1H2
|
| Chemical Name |
5-[[5-[2-(3-Aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrile lactate salt monohydrate
|
| Synonyms |
Prexasertib monolactate monohydrate Prexasertib monolactate monohydrate salt LY2606368 LY-2606368 LY 2606368.
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1120 mL | 10.5599 mL | 21.1198 mL | |
| 5 mM | 0.4224 mL | 2.1120 mL | 4.2240 mL | |
| 10 mM | 0.2112 mL | 1.0560 mL | 2.1120 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
COA