| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg | |||
| Other Sizes |
| ln Vitro |
Porphobilinogen has the ability to function as a metabolic, neuro, and phototoxin. When phototoxins are exposed to light, they destroy cells. Nerve tissue and cells can sustain harm from neurotoxins. Endogenously generated compounds known as metabolic toxins have the potential to be harmful to health when present at prolonged high concentrations [1].
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| References | |
| Additional Infomation |
Porphobilinogen is a dicarboxylic acid with aminomethyl, carboxymethyl, and 2-carboxyethyl substituents at positions 2, 3, and 4, respectively. It is a metabolite, found in both E. coli and mice. It belongs to the pyrrole class, dicarboxylic acid, and aralkylamino compounds. It is the conjugate acid of Porphobilinogen (1-). Porphobilinogen is a pyrrole compound involved in porphyrin metabolism. It is produced by ALA dehydratase and converted to hydroxymethylcholene by Porphobilinogen deaminase. Porphobilinogen is present in or produced by E. coli (K12 strain, MG1655 strain). It has been reported in humans, rapeseed, and other organisms with relevant data. Porphobilinogen is a pyrrole compound involved in porphyrin metabolism. It consists of a pyrrole ring and acetyl, propionyl, and aminomethyl side chains; it is a key monopyrrole intermediate in the biosynthesis of porphyrins, chlorophyll, and vitamin B12. Bilechromeogen is formed by the combination of two dALA molecules catalyzed by ALA dehydratase, and then converted to hydroxymethylcholesterol by bilechromeogen deaminase. Four porphyrinogen molecules condense to form one uroporphyrinogen III molecule, which is subsequently converted sequentially to coproporphyrinogen III, protoporphyrin IX, and heme. In acute intermittent porphyria and several other porphyria diseases, porphyrinogens are overproduced and excreted in the urine. Porphyrinogens are metabolites found or produced in Saccharomyces cerevisiae.
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| Molecular Formula |
C10H14N2O4
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|---|---|
| Molecular Weight |
226.22916
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| Exact Mass |
226.095
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| CAS # |
487-90-1
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| Related CAS # |
Porphobilinogen-13C2
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| PubChem CID |
1021
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| Appearance |
Off-white to light brown solid powder
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| Density |
1.421g/cm3
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| Boiling Point |
478.6ºC at 760 mmHg
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| Melting Point |
174-177ºC
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| Flash Point |
243.2ºC
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| Vapour Pressure |
5.74E-10mmHg at 25°C
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| Index of Refraction |
1.621
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| LogP |
0.818
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
16
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| Complexity |
270
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
QSHWIQZFGQKFMA-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C10H14N2O4/c11-4-8-7(3-10(15)16)6(5-12-8)1-2-9(13)14/h5,12H,1-4,11H2,(H,13,14)(H,15,16)
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| Chemical Name |
3-[5-(aminomethyl)-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.4203 mL | 22.1014 mL | 44.2028 mL | |
| 5 mM | 0.8841 mL | 4.4203 mL | 8.8406 mL | |
| 10 mM | 0.4420 mL | 2.2101 mL | 4.4203 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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