| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
Picein targets various biological molecules involved in inflammation and cell proliferation, including NF-κB, COX-2, and MMPs. By inhibiting these targets, it exerts anti-inflammatory and anti-cancer effects. It also functions as an antioxidant by scavenging reactive oxygen species.
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|---|---|
| ln Vitro |
In vitro, Picein has been shown to inhibit the proliferation of cancer cells and induce apoptosis. It reduces inflammation and oxidative stress in various cell types. Its bioactivity and potency depend on the concentration and the target molecule.
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| ln Vivo |
In vivo, Picein has been shown to reduce inflammation and oxidative stress in various animal models. It has potential therapeutic applications for conditions involving inflammation and oxidative damage. However, specific dosing and efficacy data are not extensively documented.
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| Enzyme Assay |
In vitro, cancer cells are treated with Picein at various concentrations. Cell proliferation is measured using standard assays such as MTT. The inhibition of NF-κB, COX-2, and MMPs is assessed by Western blotting or ELISA. The compound is typically dissolved in DMSO or ethanol.
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| Cell Assay |
In cell-based assays, various cell types are treated with Picein. The compound is dissolved in a suitable solvent and added to the culture medium. After incubation, effects on cell function, signal transduction, and gene expression are analyzed.
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| Animal Protocol |
In vivo, animal models of inflammation or cancer are used. Picein is administered orally or intraperitoneally. The animals are monitored for changes in inflammatory markers, tumor growth, and oxidative stress parameters.
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| ADME/Pharmacokinetics |
Dosing and administration routes would depend on the specific model. Picein has a molecular weight of 298.29 and formula C14H18O7. It is a white crystalline powder soluble in water and ethanol. It is a glucoside of piceol. It is stable under standard laboratory conditions. Storage: 4°C, sealed, protected from light.
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| Toxicity/Toxicokinetics |
Specific toxicity data are not extensively documented. As a natural product, it is generally considered to have low toxicity, but high doses may cause adverse effects. The compound is for research use only.
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| References | |
| Additional Infomation |
Picein glycoside is a glycoside. It has been reported to be found in Rhodiola rosea, Sage, and other organisms with relevant data.
Picein is also known as Ameliaroside, Piceoside, Salicinerein, and Salinigrin. It is a naturally occurring antioxidant extracted from Picrorhiza kurroa. It has been reported in Rhodiola rosea and Sage. |
| Molecular Formula |
C14H18O7
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|---|---|
| Molecular Weight |
298.28852
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| Exact Mass |
298.105
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| CAS # |
530-14-3
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| PubChem CID |
92123
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| Appearance |
Off-white to light yellow solid powder
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| Density |
1.433 g/cm3
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| Boiling Point |
562.6ºC at 760 mmHg
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| Melting Point |
195ºC
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| Flash Point |
213.2ºC
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| Index of Refraction |
1.608
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| LogP |
-0.7
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
21
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| Complexity |
353
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| Defined Atom Stereocenter Count |
5
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| SMILES |
CC(=O)C1=CC=C(C=C1)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O
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| InChi Key |
GOZCEKPKECLKNO-RKQHYHRCSA-N
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| InChi Code |
InChI=1S/C14H18O7/c1-7(16)8-2-4-9(5-3-8)20-14-13(19)12(18)11(17)10(6-15)21-14/h2-5,10-15,17-19H,6H2,1H3/t10-,11-,12+,13-,14-/m1/s1
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| Chemical Name |
1-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]ethanone
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3524 mL | 16.7622 mL | 33.5244 mL | |
| 5 mM | 0.6705 mL | 3.3524 mL | 6.7049 mL | |
| 10 mM | 0.3352 mL | 1.6762 mL | 3.3524 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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