| Size | Price | Stock | Qty |
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| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
Phosphatidylserine does not have a single defined pharmacological target. It is an endogenous phospholipid that plays a crucial role in cell membrane structure and function. It is involved in cell signaling pathways, apoptosis (programmed cell death), and the release of neurotransmitters. Its levels and location within the brain can affect important signaling pathways for cell survival and communication. It also has a protective effect on brain cells.
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| ln Vitro |
Phosphatidylserine is not evaluated for direct pharmacological activity in conventional cell-based assays. Its primary function is as a structural component of cell membranes and a modulator of cellular processes. In vitro studies focus on its role in membrane biology, apoptosis signaling (where its externalization on the cell surface serves as an "eat-me" signal for phagocytes), and neurotransmitter release. It is also used as a supplement in cell culture media to support cell growth and function.
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| ln Vivo |
Phosphatidylserine is used as a nutritional supplement to support cognitive function, memory, and brain health. It has been studied for its potential benefits in age-related cognitive decline, stress reduction, and improving exercise performance. As an endogenous compound, it is well-tolerated and has a long history of use as a dietary supplement. Its protective effects on brain cells contribute to its role in keeping the mind and memory sharp.
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| Enzyme Assay |
Phosphatidylserine does not have established receptor binding or enzyme inhibition assay protocols, as it is a nutritional supplement and endogenous phospholipid rather than a pharmacologically active drug. Its identity and purity are confirmed by standard analytical methods including HPLC and mass spectrometry. Physical properties: molecular weight 792.1 g/mol; molecular formula C42H82NO10P. No specific biochemical assay protocols are applicable for this compound.
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| Cell Assay |
Cellular studies with Phosphatidylserine focus on its role in membrane biology and apoptosis. In apoptotic cells, phosphatidylserine is externalized to the outer leaflet of the plasma membrane, where it serves as a signal for phagocytic clearance. This property is exploited in Annexin V staining assays to detect apoptosis. Phosphatidylserine is also used as a supplement in cell culture media to support cell growth and function. No specific pharmacological activity is evaluated in these studies.
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| Animal Protocol |
In vivo studies with Phosphatidylserine are conducted as part of nutritional supplementation research. Animal models are used to evaluate its effects on cognitive function, memory, and stress response. The compound is administered orally at doses corresponding to human supplementation levels. Behavioral assessments include tests of learning and memory (Morris water maze, novel object recognition). Brain tissue is collected for neurochemical analysis. Sample sizes typically range from 8-12 animals per group. Clinical studies have been conducted for cognitive enhancement and age-related cognitive decline.
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| ADME/Pharmacokinetics |
Phosphatidylserine has a molecular weight of 792.1 g/mol and a molecular formula of C42H82NO10P. It is a phospholipid in which the polar serine is linked to diacylglycerol via a phosphate ester bond. Synonyms: Serine phospholipids; Diacylglyceryl phosphate serine; PS. As a dietary supplement, it is orally administered and absorbed from the gastrointestinal tract. It is incorporated into cell membranes and metabolized via normal phospholipid turnover pathways.
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| Toxicity/Toxicokinetics |
Phosphatidylserine is generally recognized as safe (GRAS) for use as a dietary supplement. It is well-tolerated at recommended doses. Common adverse effects are rare and may include mild gastrointestinal upset. As an endogenous compound, it has a very favorable safety profile. It has been extensively studied in clinical trials for cognitive enhancement and age-related cognitive decline. No significant toxicity has been identified at supplementation levels.
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| References | |
| Additional Infomation |
1,2-Distearayoyl-sn-glycerol-3-phosphatidylserine is a 3-sn-phosphatidyl-L-serine in which both the phosphatidyl acyl groups at positions 1 and 2 are stearoyl groups. It is a mouse metabolite functionally related to octadecanoic acid. PS (18:0/18:0) is a metabolite found in or produced by Escherichia coli (K12 strain, MG1655 strain). Phosphatidylserine has also been reported in grapes (Vitis vinifera), with relevant data available. Phosphatidylserine is a phospholipid in which the polar serine is linked to diacylglycerol via a phosphate ester bond. It is a phosphatidic acid derivative in which the phosphate group is partially bound to the serine group via an ester bond.
Phosphatidylserine is also known as Serine phospholipids; Diacylglyceryl phosphate serine; PS; 1,2-Distearoyl phosphatidyl serine; Distearoylphosphatidylserine. It is abundant in the brain and protects cells. It is used as a brain-boosting supplement to support memory and cognitive function. It is available as a nutritional supplement in various formulations. No regulatory approvals as a drug have been reported; it is marketed as a dietary supplement. |
| Molecular Formula |
C42H82NO10P
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|---|---|
| Molecular Weight |
792.07
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| Exact Mass |
385.113
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| CAS # |
51446-62-9
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| PubChem CID |
9547096
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| Appearance |
White to light yellow solid powder
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
560.3±60.0 °C at 760 mmHg
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| Flash Point |
292.7±32.9 °C
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| Vapour Pressure |
0.0±3.3 mmHg at 25°C
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| Index of Refraction |
1.495
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| LogP |
0.72
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
11
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| Rotatable Bond Count |
44
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| Heavy Atom Count |
54
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| Complexity |
937
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| Defined Atom Stereocenter Count |
2
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| SMILES |
CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OC[C@@H](C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCCC
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| InChi Key |
TZCPCKNHXULUIY-RGULYWFUSA-N
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| InChi Code |
InChI=1S/C42H82NO10P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h38-39H,3-37,43H2,1-2H3,(H,46,47)(H,48,49)/t38-,39+/m1/s1
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| Chemical Name |
(2S)-2-amino-3-[[(2R)-2,3-di(octadecanoyloxy)propoxy]-hydroxyphosphoryl]oxypropanoic acid
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| Synonyms |
Phosphatidylserine(0); Distearoyl phosphatidylserine; Phosphatidylserine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~3.12 mg/mL (~3.94 mM )
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.2625 mL | 6.3126 mL | 12.6251 mL | |
| 5 mM | 0.2525 mL | 1.2625 mL | 2.5250 mL | |
| 10 mM | 0.1263 mL | 0.6313 mL | 1.2625 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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