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      PF-8380 HCl
      PF-8380 HCl

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      This product is for research use only, not for human use. We do not sell to patients.
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      InvivoChem Cat #: V4465
      CAS #: 2070015-01-7Purity ≥98%

      Description: PF-8380 HCl is a novel, potent and specific autotaxin (ATX) inhibitor with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood. PF-8380 has good oral bioavailability and exposures required for in vivo testing of autotaxin inhibition. Inhibition of ATX by PF-8380 led to decreased invasion and enhanced radiosensitization of GBM cells. Radiation-induced activation of Akt was abrogated by inhibition of ATX. Furthermore, inhibition of ATX led to diminished tumor vascularity and delayed tumor growth. These results suggest that inhibition of ATX may ameliorate GBM response to radiotherapy. Glioblastoma multiforme (GBM) is an aggressive primary brain tumor that is radio-resistant and recurs despite aggressive surgery, chemo, and radiotherapy. Autotaxin (ATX) is over expressed in various cancers including GBM and is implicated in tumor progression, invasion, and angiogenesis. 

      References:  2013 Sep 17;3:236.

      Related CAS: 1144035-53-9 (freebase)

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      PF-8380 HCl

      		Name: PF-8380 HCl

      CAS#: 2070015-01-7, 

      Related cas: 1144035-53-9 (free base)

      Chemical Formula: C₂₂H₂₂Cl₃N₃O₅
      Molecular Weight: 514.79
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Technical InformationSynonym: PF8380 HCl; PF-8380; PF 8380
      Chemical Name: 3,5-dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate hydrochloride
      InChi Key: JMSUDQYHPSNBSN-UHFFFAOYSA-N
      InChi Code: InChI=1S/C22H21Cl2N3O5/c23-16-9-14(10-17(24)12-16)13-31-22(30)27-7-5-26(6-8-27)4-3-19(28)15-1-2-18-20(11-15)32-21(29)25-18/h1-2,9-12H,3-8,13H2,(H,25,29)
      SMILES Code: O=C(N1CCN(CC1)CCC(C2=CC(O3)=C(C=C2)NC3=O)=O)OCC4=CC(Cl)=CC(Cl)=C4.[H]Cl


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        PF-8380 HCl


      Inhibition of ATX reduces Akt Phosphorylation in GBM cells grown in co-culture.  2013 Sep 17;3:236.

      		  PF-8380 HCl


      Inhibition of ATX abrogates radiation induced tumor neovascularization.  2013 Sep 17;3:236.

      		  PF-8380 HCl


      Inhibition of ATX in combination with irradiation delays tumor growth in a heterotopic tumor model of GL261.  2013 Sep 17;3:236.

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