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    PF-06873600
    PF-06873600

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4452
    CAS #: 2185857-97-8 Purity ≥98%

    Description: PF-06873600 is a novel, potent, selective and orally bioavailable inhibitor of cyclin-dependent kinase (CDK), with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively. PF-06873600 has potential antineoplastic activity. PF-06873600 selectively targets, binds to and inhibits the activity of CDKs. Inhibition of these kinases leads to cell cycle arrest, induction of apoptosis and inhibition of tumor cell proliferation. CDKs, ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and cellular proliferation, are frequently overexpressed in tumor cells.

    References: US 2018/0044344 A1.


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    PF-06873600

    Name: PF-06873600
    CAS#: 2185857-97-8
    Chemical Formula: C20H27F2N5O4S
    Exact Mass: 471.1752
    Molecular Weight: 471.5238
    Elemental Analysis: C, 50.95; H, 5.77; F, 8.06; N, 14.85; O, 13.57; S, 6.80
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: PF-06873600; PF 06873600; PF06873600;
    IUPAC/Chemical Name: Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-
    InChi Key: QIEKHLDZKRQLLN-FOIQADDNSA-N
    InChi Code: InChI=1S/C20H27F2N5O4S/c1-20(29)7-3-4-15(20)27-17-12(10-14(16(21)22)18(27)28)11-23-19(25-17)24-13-5-8-26(9-6-13)32(2,30)31/h10-11,13,15-16,29H,3-9H2,1-2H3,(H,23,24,25)/t15-,20-/m1/s1
    SMILES Code: O=C1C(C(F)F)=CC2=CN=C(NC3CCN(S(=O)(C)=O)CC3)N=C2N1[[email protected]]4[[email protected]](C)(O)CCC4


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