Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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Other Sizes |
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Purity: ≥98%
Ebvaciclib (PF-06873600; PF06873600) is a novel, potent, selective and orally bioavailable pan-inhibitor of cyclin-dependent kinase (CDK) with potential antitumor activity. With Ki values of 0.09 nM, 0.13 nM, and 0.16 nM, respectively, it inhibits CDK2, CDK4, and CDK6. PF-06873600 binds to CDKs specifically and inhibits their activity, exhibiting antineoplastic activity. Tumor cell proliferation is inhibited, apoptosis is induced, and cell cycle arrest results from inhibition of these kinases. Tumor cells often overexpress CDKs, ATP-dependent serine/threonine kinases that are key regulators of cell cycle progression and cellular proliferation.
Targets |
CDK2 (Ki = 0.1 nM); CDK6 (Ki = 0.1 nM); CDK4 (Ki = 1.2 nM)
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ln Vitro |
PF-06873600 is an cyclin-dependent kinase 2 (CDK2), CDK4, and CDK6 inhibitor with Ki values of 0.1, 1.2, and 0.1 nM, respectively.
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Animal Protocol |
Mice-bearing OVCAR3 tumors
50 mg/kg p.o. |
References |
Molecular Formula |
C20H27F2N5O4S
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Molecular Weight |
471.521290063858
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Exact Mass |
471.18
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Elemental Analysis |
C, 53.99; H, 7.29; N, 13.69; O, 12.51; S, 12.53
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CAS # |
2185857-97-8
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Appearance |
Solid powder
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SMILES |
C[C@]1(CCC[C@H]1N2C3=NC(=NC=C3C=C(C2=O)C(F)F)NC4CCN(CC4)S(=O)(=O)C)O
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InChi Key |
QIEKHLDZKRQLLN-FOIQADDNSA-N
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InChi Code |
InChI=1S/C20H27F2N5O4S/c1-20(29)7-3-4-15(20)27-17-12(10-14(16(21)22)18(27)28)11-23-19(25-17)24-13-5-8-26(9-6-13)32(2,30)31/h10-11,13,15-16,29H,3-9H2,1-2H3,(H,23,24,25)/t15-,20-/m1/s1
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Chemical Name |
6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrido[2,3-d]pyrimidin-7-one
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Synonyms |
PF06873600; Ebvaciclib; PF 06873600; PF-06873600
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.1208 mL | 10.6040 mL | 21.2080 mL | |
5 mM | 0.4242 mL | 2.1208 mL | 4.2416 mL | |
10 mM | 0.2121 mL | 1.0604 mL | 2.1208 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.