| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
|
||
| 250mg |
|
||
| 500mg |
|
||
| Other Sizes |
| Targets |
Pentaglycine does not have a specific pharmacological target in humans. Its biological role is as a structural component of the cell wall in Gram-positive bacteria. In research, it is used as a model peptide to study peptide structure, conformational dynamics, and enzymatic interactions. It has also been reported to possess various biological activities, including antimicrobial, antitumor, and immunomodulatory effects.
|
|---|---|
| ln Vitro |
In vitro, Pentaglycine is used as a model for studying peptide interactions and dynamics due to its simple structure. It serves as a substrate for enzymes that cleave peptide bonds, such as proteases and peptidoglycan hydrolases. Its role in bacterial cell wall structure makes it a target for studying the action of antibiotics that inhibit cell wall synthesis.
|
| ln Vivo |
In vivo, Pentaglycine is a naturally occurring compound found in bacterial cell walls. It is not used as a therapeutic agent in humans. Its antimicrobial, antitumor, and immunomodulatory effects have been reported, but specific in vivo efficacy data are not provided in the available sources.
|
| Enzyme Assay |
A cell-free assay for Pentaglycine would involve its use as a substrate for enzymes that cleave peptide bonds, such as proteases or peptidoglycan hydrolases. The cleavage of the peptide can be monitored by HPLC or by measuring the release of free amino acids. These assays are used to study enzyme kinetics and specificity.
|
| Cell Assay |
Cellular experiments with Pentaglycine are not typical, as it is primarily used as a model peptide in biochemical assays. Its effects on bacterial cell wall synthesis can be studied in bacterial cultures, where it can compete with the natural pentaglycine bridge for incorporation into peptidoglycan.
|
| Animal Protocol |
In vivo animal experiments for Pentaglycine are not described in the available sources. As a naturally occurring bacterial component, it is not used as a therapeutic agent in animal models.
|
| ADME/Pharmacokinetics |
Pentaglycine has a molecular formula of C10H17N5O6 and a molecular weight of 303.27 g/mol. Its CAS number is 7093-67-6. The compound is also known as Tetraglycylglycine and NSC 96353. Specific pharmacokinetic properties are not applicable as it is not a therapeutic drug. For storage, it should be kept in a cool, dry place.
|
| Toxicity/Toxicokinetics |
Toxicity data for Pentaglycine are not provided in the available sources. As a peptide, it is generally considered to have low toxicity. However, specific toxicological information is not available. It is intended for research use only and is not for human consumption.
|
| References | |
| Additional Infomation |
Pentylglycine is a pentapeptide composed of five glycine residues.
Pentaglycine (CAS: 7093-67-6) is a peptide composed of five glycine residues. Its synonyms include Gly-Gly-Gly-Gly-Gly and Tetraglycylglycine. The compound is a component of bacterial cell walls in Gram-positive bacteria and is used as a model peptide in biochemical research. It is not a therapeutic drug and is strictly for research purposes. |
| Molecular Formula |
C10H17N5O6
|
|---|---|
| Molecular Weight |
C10H17N5O6
|
| Exact Mass |
303.118
|
| CAS # |
7093-67-6
|
| PubChem CID |
81537
|
| Appearance |
White to off-white solid powder
|
| Density |
1.406g/cm3
|
| Boiling Point |
942.3ºC at 760 mmHg
|
| Flash Point |
523.7ºC
|
| Index of Refraction |
1.543
|
| LogP |
-4.9
|
| Hydrogen Bond Donor Count |
6
|
| Hydrogen Bond Acceptor Count |
7
|
| Rotatable Bond Count |
9
|
| Heavy Atom Count |
21
|
| Complexity |
424
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
MXHCPCSDRGLRER-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C10H17N5O6/c11-1-6(16)12-2-7(17)13-3-8(18)14-4-9(19)15-5-10(20)21/h1-5,11H2,(H,12,16)(H,13,17)(H,14,18)(H,15,19)(H,20,21)
|
| Chemical Name |
2-[[2-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]acetyl]amino]acetic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~5 mg/mL (~16.49 mM)
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
