Panthenol is an alcohol derivative of pantothenic acid, a component of the B vitamins and an important component of normal epithelial cell function. Panthenol exists as a racemic mixture, comprising a dextrorotatory form (dextrin) and a levorotatory form (levinrin). Although pantothenic acid is optically active, only the dextrorotatory form ([DB09357]) is biologically active. The active form of panthenol—dextrin—is enzymatically cleaved to produce pantothenic acid (vitamin B5), an important component of coenzyme A, which acts as a cofactor in many enzymatic reactions crucial for epithelial cell protein metabolism. Due to its good permeability and high local concentration, dextroparatol is used in many topical products, such as ointments and lotions for treating skin diseases, to relieve itching or promote healing. The dermatological effects of topical application of dextroparatol include promoting fibroblast proliferation and accelerating epithelial regeneration during wound healing. In addition, it has local protective and moisturizing effects and has been shown to possess anti-inflammatory properties. See also: allantoin; panthenol (ingredient); biotin; panthenol (ingredient); betaine; panthenol (ingredient)... See more...

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Drug Indications
Panthenol (a racemic mixture containing dextropanthenol and levonpanthenol) is not currently found in any FDA-approved products and therefore has no indication. Please refer to [DB09357] for FDA-approved uses of dextropanthenol.

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Mechanism of Action
Panthenol is an alcohol derivative of pantothenic acid, a component of the B vitamins and an important component of normal epithelial cell function. Dextropanthenol is the active form of panthenol, which is enzymatically cleaved to produce pantothenic acid (vitamin B5), an important component of coenzyme A, which acts as a cofactor in many enzymatic reactions crucial for epithelial cell protein metabolism. Topical application of dextropanthenol has dermatological effects including promoting fibroblast proliferation and accelerating epithelial regeneration in wound healing. In addition, it has local protective and moisturizing effects and has been shown to possess anti-inflammatory properties.

C9H19NO4

205.254

205.131

16485-10-2

D-Panthenol;81-13-0

4678

White to off-white solid powder

1.2±0.1 g/cm3

483.6±45.0 °C at 760 mmHg

66-69 °C(lit.)

246.3±28.7 °C

0.0±2.8 mmHg at 25°C

1.502

-0.92

4

4

6

14

182

0

O([H])C([H])(C(N([H])C([H])([H])C([H])([H])C([H])([H])O[H])=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])O[H]

SNPLKNRPJHDVJA-UHFFFAOYSA-N

InChI=1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)

2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide

Dexpanthenol; Panthenol

2934.99.9001

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

H2O : ~100 mg/mL (~487.21 mM)
DMSO : ≥ 46 mg/mL (~224.12 mM)

Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.

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Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)
*Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution.
Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline)
Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil)
Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals).

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Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)]
*Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.
Injection Formulation 5: 2-Hydroxypropyl-β-cyclodextrin : Saline = 50 : 50 (i.e. 500 μL 2-Hydroxypropyl-β-cyclodextrin → 500 μL Saline)
Injection Formulation 6: DMSO : PEG300 : castor oil : Saline = 5 : 10 : 20 : 65 (i.e. 50 μL DMSO → 100 μLPEG300 → 200 μL castor oil → 650 μL Saline)
Injection Formulation 7: Ethanol : Cremophor : Saline = 10： 10 : 80 (i.e. 100 μL Ethanol → 100 μL Cremophor → 800 μL Saline)
Injection Formulation 8: Dissolve in Cremophor/Ethanol (50 : 50), then diluted by Saline
Injection Formulation 9: EtOH : Corn oil = 10 : 90 (i.e. 100 μL EtOH → 900 μL Corn oil)
Injection Formulation 10: EtOH : PEG300：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL EtOH → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline)

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Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium)
Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose
Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals).

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Oral Formulation 3: Dissolved in PEG400
Oral Formulation 4: Suspend in 0.2% Carboxymethyl cellulose
Oral Formulation 5: Dissolve in 0.25% Tween 80 and 0.5% Carboxymethyl cellulose
Oral Formulation 6: Mixing with food powders

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Note: Please be aware that the above formulations are for reference only. InvivoChem strongly recommends customers to read literature methods/protocols carefully before determining which formulation you should use for in vivo studies, as different compounds have different solubility properties and have to be formulated differently.

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 (Please use freshly prepared in vivo formulations for optimal results.)