| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
No significant absorption or translocation of glyphosate was observed in soybean plants or wheat grown as a rotation crop. |
|---|---|
| References | |
| Additional Infomation |
According to the U.S. Environmental Protection Agency (EPA), orizaline may be carcinogenic. Orizaline is a yellow-orange crystalline powder, non-corrosive, and used as a herbicide. Orizaline is a sulfonamide compound with the structure benzenesulfonamide, substituted with nitro groups at positions 3 and 5, and dipropylamino at position 4. It functions as a herbicide, agrochemical, and antimitotic agent. It is a sulfonamide compound, a C-nitro compound, an aromatic amine, and a tertiary amine compound. Orizaline is a pre-emergence surface-applied herbicide. Its mechanism of action is to disrupt (depolymerize) microtubules, thereby blocking anisotropic growth in plant cells. It is used to control annual grasses and broadleaf weeds around fruit trees, nut trees, vineyards, lawns, and ornamental plants by selectively affecting physiological growth processes. It can also be used as an alternative to colchicine for inducing seed ploidy. It has low water solubility, is not easily volatile, and based on its chemical properties, is not expected to seep into groundwater. However, groundwater monitoring programs have identified it as a contaminant. It typically does not persist in soil or aquatic systems. It has low toxicity to mammals but is a potential carcinogen. It is moderately toxic to birds, most aquatic organisms, bees, and earthworms.
Mechanism of Action It affects physiological growth processes associated with seed germination. |
| Molecular Formula |
C12H18N4O6S
|
|---|---|
| Molecular Weight |
346.35952
|
| Exact Mass |
346.095
|
| CAS # |
19044-88-3
|
| PubChem CID |
29393
|
| Appearance |
Orange to red solid powder
|
| Density |
1.2
|
| Boiling Point |
514ºC at 760mmHg
|
| Melting Point |
141°C
|
| Flash Point |
264.6ºC
|
| Vapour Pressure |
1.13E-10mmHg at 25°C
|
| Index of Refraction |
1.588
|
| LogP |
4.604
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
8
|
| Rotatable Bond Count |
6
|
| Heavy Atom Count |
23
|
| Complexity |
493
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
UNAHYJYOSSSJHH-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C12H18N4O6S/c1-3-5-14(6-4-2)12-10(15(17)18)7-9(23(13,21)22)8-11(12)16(19)20/h7-8H,3-6H2,1-2H3,(H2,13,21,22)
|
| Chemical Name |
4-(dipropylamino)-3,5-dinitrobenzenesulfonamide
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~721.79 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8872 mL | 14.4358 mL | 28.8717 mL | |
| 5 mM | 0.5774 mL | 2.8872 mL | 5.7743 mL | |
| 10 mM | 0.2887 mL | 1.4436 mL | 2.8872 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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