My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    ω-Conotoxin GVIA
    ω-Conotoxin GVIA

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V34701
    CAS #: 106375-28-4Purity ≥98%

    Description: ω-Conotoxin GVIA, a peptide compound, is a neurotoxin that acts as a potent antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC50 = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors).    

    References: 

    Lalo, U.V., et al. 2001. Brain Res. Bull.54, 507.
    Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
    Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
    Olivera, B.M., et al. 1991. J. Biol. Chem.266, 22067.
    Protti, D.A., et al. 1991. Brain Res.557, 336.
    Werth, J.L., et al. 1991. Mol. Pharmacol.40, 742.
    Koyano, K., et al. 1987. Eur. J. Pharmacol.135, 337.
    Abe, T., et al. 1986. Neurosci. Lett.71, 203.         

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Related Products
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review

    M.Wt: 3037.35

    CAS No.: 106375-28-4

    Formula: C120H182N38O43S6

    Solubility in water: 1 mg/ml

    Synonyms: ω-CgTx GVIA, ω-Conotoxin GVIA, Conus geographus

    SMILES:C[[email protected]](O)([H])[[email protected]@](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]]1([H])C[[email protected]](O)([H])CN12)([H])CC3=CC=C(O)C=C3)([H])/C(O)=N/[[email protected]@](/C(O)=N/[[email protected]@](/C(O)=N\[[email protected]@](/C(O)=N\[[email protected]@](C(O)=N)([H])CC4=CC=C(O)C=C4)([H])CSSC[[email protected]@](N=C(O)[[email protected]](N=C(O)[[email protected]](N=C(O)[[email protected]](N=C(O)[[email protected]](N=C(O)[[email protected]]5([H])C[

    Sequence:H-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂ (disulfide bonds: 1 → 16; 8 → 19; 15 → 26) 


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2

    These protocols are for reference only. InvivoChem does not independently validate these methods.

    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      prompt
      Do you confirm the receipt?