| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Chemical intermediate
Oleic acid chloride is a reactive chemical intermediate and does not have a specific pharmacological target. It is used to introduce the oleoyl group into other molecules. It may be used to synthesize oleic acid derivatives with biological activity. |
|---|---|
| ln Vitro |
Oleoyl chloride is a biochemical reagent that can be utilized in research pertaining to life sciences as an organic substance or biological material.
In vitro, oleic acid chloride is not typically used for biological activity assays due to its reactivity. It is used in chemical synthesis to prepare compounds that are then tested for biological activity. It can react with proteins and other biomolecules, which may lead to non-specific effects. |
| ln Vivo |
In vivo, oleic acid chloride is not administered as a drug. It is a chemical intermediate and is used in the synthesis of pharmaceutical compounds. Its safety and toxicology are related to its reactivity and potential for hydrolysis to oleic acid and hydrochloric acid.
|
| Enzyme Assay |
For non-cellular assays, oleic acid chloride can be characterized using analytical techniques such as GC, HPLC, and NMR. Its purity and reactivity can be assessed. It can be used in chemical synthesis to prepare derivatives for further testing.
|
| Cell Assay |
For in vitro cell-based assays, oleic acid chloride is not typically used directly. The compounds synthesized from it can be tested in cell culture models for biological activity, cytotoxicity, and other effects.
|
| Animal Protocol |
For in vivo animal studies, oleic acid chloride is not administered directly. The compounds synthesized from it can be tested in animal models for efficacy and safety.
|
| ADME/Pharmacokinetics |
Pharmacokinetic properties include solubility in organic solvents such as dichloromethane, chloroform, and hexane. It is reactive with water and alcohols, hydrolyzing to oleic acid and hydrochloric acid. It should be stored under inert atmosphere and protected from moisture. It is a liquid and should be handled with care due to its reactivity and pungent odor.
|
| Toxicity/Toxicokinetics |
Toxicological data for oleic acid chloride is related to its reactivity. It is corrosive and can cause burns upon contact with skin and eyes. Inhalation of vapors can cause respiratory irritation. It is not for human use. It should be handled with appropriate safety precautions, including the use of gloves, goggles, and fume hoods.
|
| Additional Infomation |
Intermediates; surfactants (surfactants)
Oleic acid chloride is a fatty acid chloride used as a chemical intermediate. It is used in the synthesis of surfactants, lubricants, and pharmaceuticals. It is reactive with nucleophiles and hydrolyzes to oleic acid and hydrochloric acid. It is corrosive and should be handled with care. |
| Molecular Formula |
C18H33CLO
|
|---|---|
| Molecular Weight |
300.90700
|
| Exact Mass |
300.221
|
| CAS # |
112-77-6
|
| PubChem CID |
5364783
|
| Appearance |
Colorless to light yellow liquid
|
| Density |
0.9±0.1 g/cm3
|
| Boiling Point |
378.0±21.0 °C at 760 mmHg
|
| Flash Point |
182.0±15.2 °C
|
| Vapour Pressure |
0.0±0.9 mmHg at 25°C
|
| Index of Refraction |
1.464
|
| LogP |
8.44
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
15
|
| Heavy Atom Count |
20
|
| Complexity |
236
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CCCCCCCC/C=C\CCCCCCCC(=O)Cl
|
| InChi Key |
MLQBTMWHIOYKKC-KTKRTIGZSA-N
|
| InChi Code |
InChI=1S/C18H33ClO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3/b10-9-
|
| Chemical Name |
(Z)-octadec-9-enoyl chloride
|
| Synonyms |
Oleoyl chloride; Oleic acid chloride; 112-77-6; (Z)-octadec-9-enoyl chloride; 9-Octadecenoyl chloride, (Z)-; Oleic chloride; (9Z)-9-Octadecenoyl chloride; U83VP176UX;
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3233 mL | 16.6163 mL | 33.2325 mL | |
| 5 mM | 0.6647 mL | 3.3233 mL | 6.6465 mL | |
| 10 mM | 0.3323 mL | 1.6616 mL | 3.3233 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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