| Size | Price | Stock | Qty |
|---|---|---|---|
| 25g |
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| Other Sizes |
| Targets |
Octenyl succinic anhydride targets the hydroxyl (-OH) groups on starch and other polysaccharide molecules. It does not target biological receptors but is a chemical esterification agent, reacting with polysaccharides to form octenyl succinate derivatives (OS-starch).
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|---|---|
| ln Vitro |
In cell-free esterification reactions, OSA reacts with starch in aqueous alkaline conditions (pH 8-9) to form OS-starch. This modified starch acts as an effective stabilizer and emulsifier, improving the interaction between molecules on the outer surfaces of starch granules.
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| ln Vivo |
In vivo activity is not applicable as OSA is a chemical reagent for food, cosmetic, and pharmaceutical applications. It is not a pharmacologically active compound for systemic administration. OS-starch has been studied as a drug delivery carrier for oral administration, improving bioavailability of poorly water-soluble drugs.
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| Enzyme Assay |
For esterification of starch: Starch (20-40% suspension) is adjusted to pH 8.0-8.5 with 3% NaOH. OSA (3-5% based on starch weight) is added dropwise over 2-4 hours with continuous stirring at 25-40degC, maintaining pH 8.0-8.5. After pH stabilizes (8.0-8.5), the reaction continues for 1-2 hours. The product is washed with water and ethanol, then dried. For IR spectroscopy: Analyze the ester carbonyl peak at ~1724 cm-1.
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| Cell Assay |
OSA is not used in live-cell assays as it is a chemical reagent. For evaluating OS-starch-cell interactions, Caco-2 or intestinal epithelial cells are incubated with fluorescently labeled OS-starch (0.1-10 mg/mL) for 2-24 hours. Cellular uptake is visualized by confocal microscopy. Cell viability is assessed by MTT. For drug delivery, curcumin or other hydrophobic drugs are loaded into OS-starch nanoparticles. Release kinetics are measured in vitro.
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| Animal Protocol |
OSA is not administered to animals as it is a reactive chemical. OS-starch, however, can be orally administered to rodents as a drug carrier (e.g., 10-100 mg/kg) for pharmacokinetic studies. Blood samples are collected at various time points, and drug concentrations are analyzed by HPLC-MS. Intestinal absorption and bioavailability of encapsulated drugs are assessed.
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| ADME/Pharmacokinetics |
OSA is a reactive chemical, not a drug. It hydrolyzes under humid conditions to octenyl succinic acid. Storage: at room temperature in a sealed, dry container. MW: 210.27; formula: C12H18O3. Appearance: colorless to light yellow liquid. Density: 1 g/mL. For in vitro use, soluble in organic solvents (acetone, ethanol).
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| Toxicity/Toxicokinetics |
OSA is an irritant (Xi: R36/38). It can cause irritation to eyes and skin. Use safety glasses and gloves. Avoid dust and aerosol formation. If contact occurs, rinse immediately with plenty of water. Handle in a well-ventilated area with personal protective equipment. Not for human consumption in its reactive form.
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| Additional Infomation |
This is a research-grade chemical reagent, not a drug. It is widely used in the food industry as an emulsifier, stabilizer, and thickener (E1450). In cosmetics, it is used as a texture enhancer. In pharmaceuticals, OS-starch is used as a carrier for controlled release and drug solubilization. Also used as a curing agent for epoxy resins.
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| Molecular Formula |
C12H18O3
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|---|---|
| Molecular Weight |
210.26952
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| Exact Mass |
210.126
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| CAS # |
26680-54-6
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| PubChem CID |
5362721
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| Appearance |
Colorless to light yellow liquid（Density：1 g/cm3）
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| Density |
1 g/mL at 25ºC(lit.)
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| Boiling Point |
179ºC
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| Melting Point |
41863ºC
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| Flash Point |
163ºC
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| Vapour Pressure |
0.000193mmHg at 25°C
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| Index of Refraction |
n20/D 1.4694(lit.)
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| LogP |
2.602
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
15
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| Complexity |
256
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1(/C=C/CCCCCC)C(=O)OC(=O)C1
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 250 mg/mL (~1188.95 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.7558 mL | 23.7790 mL | 47.5579 mL | |
| 5 mM | 0.9512 mL | 4.7558 mL | 9.5116 mL | |
| 10 mM | 0.4756 mL | 2.3779 mL | 4.7558 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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