| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
Octadecanal does not have a specific well-defined pharmacological target, as it is primarily used as a chemical intermediate and research reagent rather than a therapeutic agent. As a long-chain aldehyde, it can interact with biological membranes and may affect membrane fluidity and permeability. It can also act as a substrate for aldehyde dehydrogenases and other metabolizing enzymes. In biological systems, octadecanal is a component of lipid metabolism and is involved in the synthesis of complex lipids.
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|---|---|
| ln Vitro |
Octadecanal exhibits in vitro activity primarily as a chemical reagent and intermediate. It is used in the synthesis of various organic compounds. In biological research, it may be used as a standard in chromatographic analysis or as a substrate for studying aldehyde metabolism. Its effects on biological membranes can be studied using biophysical techniques. These assays are used in lipid research and membrane biology.
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| ln Vivo |
Octadecanal is not typically used as a therapeutic agent in vivo. However, as a component of lipid metabolism, it is involved in various physiological processes. In toxicological studies, octadecanal may be evaluated for its effects on skin and respiratory irritation. Its metabolic fate in vivo involves oxidation to stearic acid via aldehyde dehydrogenase, followed by beta-oxidation. These studies help define the safety profile of long-chain aldehydes for industrial applications.
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| Enzyme Assay |
Octadecanal does not have specific enzyme/receptor binding assays associated with it, as it is not a typical drug target compound. However, its interaction with biological membranes can be studied using biophysical techniques. Its metabolism by aldehyde dehydrogenase can be assayed spectrophotometrically by measuring NADH production. These assays are used in toxicological and metabolic studies rather than in drug discovery.
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| Cell Assay |
Octadecanal is not typically used in cellular assays as a pharmacological agent. However, its effects on cell membranes can be studied using cell culture models. Cytotoxicity assays (e.g., MTT or LDH release) can be performed to assess the compound's effects on cell viability. Membrane permeability assays can be used to measure its effects on cell membrane integrity. These assays are primarily used in toxicological research.
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| Animal Protocol |
In vivo animal experiments with octadecanal are primarily conducted for toxicological evaluation. Rodent models are used to assess acute and subchronic toxicity via oral, dermal, or inhalation routes. Clinical signs, body weight, and organ weights are monitored. Histopathological examination of tissues is performed to assess target organ toxicity. Dermal irritation and sensitization studies are conducted in rabbits or guinea pigs. These studies are important for assessing the safety of octadecanal for use in consumer products and industrial applications.
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| ADME/Pharmacokinetics |
Octadecanal is a lipophilic compound with low water solubility. It is well absorbed after oral administration and is metabolized primarily by oxidation to stearic acid via aldehyde dehydrogenase. The resulting fatty acid undergoes beta-oxidation to produce acetyl-CoA. The compound is excreted as carbon dioxide and water. Its dermal absorption is limited. The pharmacokinetic profile of octadecanal is typical for long-chain fatty aldehydes.
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| Toxicity/Toxicokinetics |
Octadecanal is considered to have low acute toxicity. It is a mild skin and eye irritant but is not considered a skin sensitizer. Inhalation of high concentrations may cause respiratory irritation. The compound is not classified as a carcinogen or mutagen. Standard laboratory safety precautions should be followed when handling this compound.
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| References | |
| Additional Infomation |
Octadecanal is an aldehyde containing α-CH2. It has been reported to exist in frangipani, daphne, and other organisms with relevant data.
Octadecanal is a long-chain aliphatic aldehyde used as a chemical intermediate and research reagent. It is also known as stearaldehyde, stearyl aldehyde, or 1-octadecanal. The compound is present in both thigh and breast muscle. It is available in high purity (≥95%) for research applications. Its role as a building block in organic synthesis makes it a valuable tool in chemical research. |
| Molecular Formula |
C18H36O
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|---|---|
| Molecular Weight |
268.4778
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| Exact Mass |
268.277
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| CAS # |
638-66-4
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| PubChem CID |
12533
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| Appearance |
White to off-white solid powder
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| Density |
0.831g/cm3
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| Boiling Point |
321.3ºC at 760 mmHg
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| Melting Point |
46 °C
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| Flash Point |
154.5ºC
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| Index of Refraction |
1.443
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| LogP |
6.446
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
16
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| Heavy Atom Count |
19
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| Complexity |
165
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
FWWQKRXKHIRPJY-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C18H36O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19/h18H,2-17H2,1H3
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| Chemical Name |
octadecanal
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO :< 1 mg/mL
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7247 mL | 18.6234 mL | 37.2467 mL | |
| 5 mM | 0.7449 mL | 3.7247 mL | 7.4493 mL | |
| 10 mM | 0.3725 mL | 1.8623 mL | 3.7247 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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