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    Noradrenaline bitartrate monohydrate
    Noradrenaline bitartrate monohydrate

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1122
    CAS #: 108341-18-0 Purity ≥98%

    Description: Noradrenaline bitartrate monohydrate (Levophed; NSC169106; Arterenol bitartrate; Noradrenalin bitartrate; NSC-169106; Levarterenol bitartrate monohydrate), the bitartrate salt and hydrated form of Noradrenaline, is a direct-acting alpha-adrenergic receptors agonist / stimulator. It is a catecholamine that functions in the brain and body as both a hormone and neurotransmitter.

    References: Trends Neurosci. 2005 Nov;28(11):574-82.; Int Clin Psychopharmacol. 2003 Jul;18(4):191-202.

    Related CAS #: 69815-49-2 (bitartrate)   51-41-2 (free base)   55-27-6 (HCl)   108341-18-0 (bitartrate hydrate)   

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    • 香港大学
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    Molecular Weight (MW)337.28 
    FormulaC8H11NO3.C4H6O6.H2O 
    CAS No.108341-18-0 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 64 mg/mL (189.7 mM) 
    Water: 64 mg/mL (189.7 mM) 
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 1,2-Benzenediol, 4-((1R)-2-amino-1-hydroxyethyl)-, (2R,3R)-2,3-dihydroxybutanedioate hydrate

    InChi Key: LNBCGLZYLJMGKP-LUDZCAPTSA-N

    InChi Code: InChI=1S/C8H11NO3.C4H6O6.H2O/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10;/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10);1H2/t8-;1-,2-;/m01./s1

    SMILES Code: OC1=CC=C([[email protected]@H](O)CN)C=C1O.O=C(O)[[email protected]](O)[[email protected]@H](O)C(O)=O.[H]O[H]

    SynonymsLevophed; Norepinephrine bitartrate; NSC169106; Arterenol bitartrate; Levophed; Noradrenalin bitartrate; NSC-169106; NSC 169106; Levarterenol bitartrate monohydrate; L-Noradrenaline bitartrate monohydrate


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    In Vitro

    In vitro activity: Noradrenaline modulates the gain of evoked activity, especially in sensory areas. Noradrenaline promotes long-term synaptic plasticity, in addition to these data emphasizing its short-term influence. Noradrenaline would signal ‘gross changes in the environment that produce sensory information strongly violating top-down expectations’ and would, through an enhancement of ‘bottom-up’ information processing at the expense of irrelevant ‘top-down’ expectations, favor behavioral adjustment. Noradrenaline modulates drive and energy and exerts a fine regulation of specific processes including learning, memory, sleep, arousal and adaptation. Noradrenaline system is intimately involved in a range of psychological processes which, when disrupted, lead to the expression of classifiable psychiatric disorders. Noradrenaline appears to be involved in a range of psychological processes, including arousal (vigilance), cognition, learning and sleep regulation, and also in regulating response to stressors which might initiate or exacerbate depressive symptomatology. Noradrenaline deficiency in this pathway may reduce concentration, affect working memory and cause psychomotor retardation, resulting in apathy and depression,while an increase in noradrenaline in this pathway is predicted to alleviate poor concentration, apathy and depression. Noradrenaline effects are complex and depending on experimental conditions (ponto-medullary and medullary preparations) and species (rats or mice), exogenous Noradrenaline mainly facilitates or mainly inhibits the neonatal RRG, with a mixture of α1 facilitatory and α2 inhibitory effects.

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    References

    Trends Neurosci. 2005 Nov;28(11):574-82.; Int Clin Psychopharmacol. 2003 Jul;18(4):191-202. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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