| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg | |||
| Other Sizes |
Purity: ≥98%
| Targets |
The primary targets of neoisoliquiritin include inflammatory signaling pathways and oxidative stress-responsive pathways. The compound exhibits antioxidant activity through free radical scavenging mechanisms. Its anti-inflammatory effects are mediated through inhibition of pro-inflammatory cytokine production and modulation of NF-κB signaling. The compound also demonstrates anti-cancer activity through induction of apoptosis in cancer cell lines.
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| ln Vitro |
In vitro, neoisoliquiritin exhibits antioxidant activity through free radical scavenging. It demonstrates anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines. The compound also shows anti-cancer activity by inducing apoptosis in various cancer cell lines. Its effects on cell signaling pathways have been characterized in cellular models, with modulation of NF-κB and other inflammatory pathways observed.
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| ln Vivo |
In vivo studies on neoisoliquiritin are limited. Based on its mechanism of action, the compound may have potential in inflammatory disorders and cancer. Its antioxidant properties suggest potential in oxidative stress-related conditions. Further in vivo studies are needed to fully characterize its pharmacological effects and therapeutic potential.
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| Enzyme Assay |
For in vitro antioxidant assays, neoisoliquiritin can be evaluated using DPPH or ABTS radical scavenging assays. The compound is incubated with radical solutions, and the decrease in absorbance is measured. Scavenging activity is calculated as a percentage. Anti-inflammatory activity can be assessed by measuring inhibition of pro-inflammatory cytokine production in stimulated cells.
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| Cell Assay |
For in vitro cell-based assays, neoisoliquiritin is typically tested on immune cells or cancer cell lines. Cells are treated with the compound at various concentrations (typically 1-100 μM) for 24-72 hours. Cell viability is assessed using MTT or CCK-8 assays. Cytokine production is measured by ELISA. Apoptosis is evaluated by flow cytometry. Signaling pathway modulation is assessed by Western blotting.
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| Animal Protocol |
In vivo animal experiments for neoisoliquiritin have not been extensively reported. Based on its anti-inflammatory and anti-cancer activities, potential experimental models include inflammation models and xenograft tumor models in mice. The compound could be administered orally or intraperitoneally, with inflammatory markers or tumor volume assessed as pharmacodynamic endpoints.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for neoisoliquiritin are limited. As a flavonoid glycoside, it is expected to have moderate oral bioavailability. The compound may undergo metabolism in the gastrointestinal tract and liver. Standard pharmacokinetic studies would be required to determine its absorption, distribution, metabolism, and excretion profile.
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| Toxicity/Toxicokinetics |
Toxicological data for neoisoliquiritin are limited. As a natural product isolate, it is generally considered to have low toxicity at pharmacological doses. However, comprehensive toxicological studies have not been extensively reported. The compound is classified as a research-grade reagent and is not for human use.
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| Additional Infomation |
Isoliquiritin is a monosaccharide derivative with the structure trans-chalcone, substituted with hydroxyl groups at the 2' and 4' positions and with a β-D-glucopyranoside at the 4' position. It possesses antitumor activity and is also a plant metabolite. Isoliquiritin belongs to the chalcone, resorcinol, β-D-glucoside, and monosaccharide derivative classes. Its function is related to trans-chalcone. Isoliquiritin has been reported to be found in licorice (Glycyrrhiza uralensis), licorice root (Glycyrrhiza aspera), and other organisms with relevant data. See also: Glycyrrhiza glabra (partial).
Neoisoliquiritin is a research-use only compound and has not been approved for clinical applications. The compound is a flavonoid glycoside related to isoliquiritin. Its molecular weight and formula are well-characterized. It is available from various research chemical suppliers. Further research is needed to fully elucidate its pharmacological profile and therapeutic potential. |
| Molecular Formula |
C21H22O9
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|---|---|
| Molecular Weight |
418.3940
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| Exact Mass |
418.126
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| CAS # |
7014-39-3
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| PubChem CID |
5318591
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| Appearance |
Light yellow to yellow solid powder
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| Density |
1.528
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| Boiling Point |
743.5±60.0 °C at 760 mmHg
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| Melting Point |
230-232℃
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| Flash Point |
263.3±26.4 °C
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| Vapour Pressure |
0.0±2.6 mmHg at 25°C
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| Index of Refraction |
1.707
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| LogP |
0.76
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| Hydrogen Bond Donor Count |
6
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| Hydrogen Bond Acceptor Count |
9
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
30
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| Complexity |
589
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| Defined Atom Stereocenter Count |
5
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| SMILES |
O1C([H])(C([H])(C([H])(C([H])(C1([H])C([H])([H])O[H])O[H])O[H])O[H])OC1C([H])=C([H])C(/C(/[H])=C(\[H])/C(C2C([H])=C([H])C(=C([H])C=2O[H])O[H])=O)=C([H])C=1[H]
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| InChi Key |
YNWXJFQOCHMPCK-LXGDFETPSA-N
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| InChi Code |
InChI=1S/C21H22O9/c22-10-17-18(26)19(27)20(28)21(30-17)29-13-5-1-11(2-6-13)3-8-15(24)14-7-4-12(23)9-16(14)25/h1-9,17-23,25-28H,10H2/b8-3+/t17-,18-,19+,20-,21-/m1/s1
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| Chemical Name |
(E)-1-(2,4-dihydroxyphenyl)-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]prop-2-en-1-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3901 mL | 11.9506 mL | 23.9011 mL | |
| 5 mM | 0.4780 mL | 2.3901 mL | 4.7802 mL | |
| 10 mM | 0.2390 mL | 1.1951 mL | 2.3901 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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