| Size | Price | |
|---|---|---|
| 5g | ||
| Other Sizes |
| Targets |
Napropamide targets DNA synthesis and cell division in plants. It interferes with lipid and protein synthesis in germinating seeds. Its primary mechanism is the inhibition of root development, which prevents the establishment of weeds.
|
|---|---|
| ln Vitro |
In vitro studies on napropamide focus on its herbicidal activity. Its effect on cell division is studied in plant cell cultures. Its mechanism of action involves inhibiting DNA synthesis and cell division in plant cells.
|
| ln Vivo |
In vivo, napropamide is applied to soil as a pre-emergent herbicide to control weeds. It is effective against a number of annual grasses and broad-leaved weeds. It is used in fields, turf, and ornamental plant settings.
|
| Enzyme Assay |
Napropamide is not a drug and does not have a typical enzyme/receptor binding assay. Its herbicidal activity is assessed in plant-based bioassays that measure its effect on root growth and seedling development. It is a standard agrochemical.
|
| Cell Assay |
Cellular assays for napropamide are conducted using plant cells or tissues. These assays measure its effect on cell division and DNA synthesis. They are used to study its mechanism of action and to evaluate its herbicidal potency.
|
| Animal Protocol |
In vivo experiments for napropamide are conducted in greenhouses and fields. They involve applying the herbicide to soil and assessing its efficacy in controlling target weeds while being safe for the crop. These studies are essential for agricultural product development.
|
| ADME/Pharmacokinetics |
Napropamide is a small molecule with a molecular weight of 271.35 g/mol. Its environmental fate and behavior in soil are characterized. It has a half-life of 24 to 131 days and is susceptible to photodegradation. Its persistence in the environment is a factor in its use.
|
| Toxicity/Toxicokinetics |
Toxicity Data
LC50 (Rat): >4,800 mg/m3 Non-human Toxicity Values LD50 (Rat, Acute Oral): >5,000 mg/kg Napropamide has low mammalian toxicity, with an oral LD50 in mice of >5 g/kg. It is considered safe for use in agriculture when label directions are followed. It is not intended for human consumption. Regulatory bodies have established acceptable exposure limits. |
| Additional Infomation |
N,N-Diethyl-2-(naphthalene-1-oxy)propionamide is a monocarboxylic acid amide with the structure propionamide, where the nitrogen atom is replaced by two ethyl groups and the 2-position by a naphthalene-1-oxy group. It is an aromatic ether, belonging to the monocarboxylic acid amide class and is also a naphthalene compound. N-N-propionamide is a selective systemic amide herbicide. This compound can be used to control a variety of annual grasses and broadleaf weeds. N-N-propionamide can be applied to fields planted with vegetables, fruit trees, shrubs, grapevines, strawberries, sunflowers, tobacco, olives, mint, lawns, or other crops. This compound is absorbed by plant roots and exerts its effect by inhibiting root development and growth.
Napropamide is a widely used herbicide in agriculture. It is a member of the amide herbicide class. Its pre-emergent activity and selectivity make it a valuable tool for weed control in many crops. It is available under various trade names. |
| Molecular Formula |
C17H21NO2
|
|---|---|
| Molecular Weight |
271.36
|
| Exact Mass |
271.157
|
| CAS # |
15299-99-7
|
| PubChem CID |
27189
|
| Appearance |
Colorless crystals; (tech., brown solid)
Brown solid Light brown solid from n-pentane. White crystals when pure |
| Density |
1.1±0.1 g/cm3
|
| Boiling Point |
430.2±28.0 °C at 760 mmHg
|
| Melting Point |
73-78 °C(lit.)
|
| Flash Point |
214.0±24.0 °C
|
| Vapour Pressure |
0.0±1.0 mmHg at 25°C
|
| Index of Refraction |
1.568
|
| LogP |
3.24
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
5
|
| Heavy Atom Count |
20
|
| Complexity |
314
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC(OC1=C2C=CC=CC2=CC=C1)C(N(CC)CC)=O
|
| InChi Key |
WXZVAROIGSFCFJ-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C17H21NO2/c1-4-18(5-2)17(19)13(3)20-16-12-8-10-14-9-6-7-11-15(14)16/h6-13H,4-5H2,1-3H3
|
| Chemical Name |
N,N-diethyl-2-naphthalen-1-yloxypropanamide
|
| Synonyms |
Waylay; Devrinol; Napropamide
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 42 mg/mL (~154.78 mM)
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6851 mL | 18.4257 mL | 36.8514 mL | |
| 5 mM | 0.7370 mL | 3.6851 mL | 7.3703 mL | |
| 10 mM | 0.3685 mL | 1.8426 mL | 3.6851 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
