| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
| ln Vitro |
Compound 14 (NAB-14) has an IC50 of 15 µM and 5.1 µM, respectively, which inhibits the GluN1/2AC1/2CC2 and GluN1/2AC1/2CC2 receptors [1]. Although native GluN2A or GluN2B-containing NMDARs in cultured cortical neurons are unaffected by NAB-14 (20 µM; 24 hours), it inhibits native GluN2D-containing receptors in brain slices [1]. The evoked EPSCs' peak amplitude is reduced to 55 ± 3.0% and the τW of EPSC inactivation is dramatically decreased by NAB-14 (10 µM) [1]. The amount of NAB-14 (10 µM) that decreased the interneuron EPSCs' peak amplitude and charge transfer to 59 ± 9.9% and 63 ± 9.7%, respectively. NAB-14 lowers interneuron EPSCs' τW from 150 ± 12 ms to 101 ± 14 ms[1].
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| ln Vivo |
NAB-14 (20 mg/kg; oral) causes a significant systemic exposure; in mice and rats, peak brain free concentrations are 3.2 and 3.8 nM, respectively [1].
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| Animal Protocol |
Animal/Disease Models: Mice and rats [1]
Doses: 20 mg/kg Route of Administration: Oral Experimental Results: Demonstrated high systemic exposure, with peak intracerebral peaks of 3.2 and 3.8 nM in mice and rats, respectively. |
| References |
| Molecular Formula |
C20H21N3O3
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|---|---|
| Molecular Weight |
351.399044752121
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| Exact Mass |
351.158
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| CAS # |
1237541-73-9
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| PubChem CID |
46862257
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| Appearance |
White to off-white solid powder
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| LogP |
3.4
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
26
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| Complexity |
487
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O(C1C=CC(=CC=1)C(NC1=CC=CC2C=CNC=21)=O)C(N(CC)CC)=O
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| InChi Key |
WCGIKJOMEYPSIP-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C20H21N3O3/c1-3-23(4-2)20(25)26-16-10-8-15(9-11-16)19(24)22-17-7-5-6-14-12-13-21-18(14)17/h5-13,21H,3-4H2,1-2H3,(H,22,24)
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| Chemical Name |
[4-(1H-indol-7-ylcarbamoyl)phenyl] N,N-diethylcarbamate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~200 mg/mL (~569.2 mM; with ultrasonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5 mg/mL (14.23 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8458 mL | 14.2288 mL | 28.4576 mL | |
| 5 mM | 0.5692 mL | 2.8458 mL | 5.6915 mL | |
| 10 mM | 0.2846 mL | 1.4229 mL | 2.8458 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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