| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
The primary applications of N-Piperidinoethanol are as a chemical intermediate and as a reagent in organic synthesis. It is not a drug with a specific biological target but is used as a building block for the synthesis of various pharmaceuticals and other compounds. The compound's piperidine ring and hydroxyethyl side chain make it a versatile intermediate for the introduction of the piperidine moiety into target molecules. It is used in the synthesis of local anesthetics, antihistamines, and other drugs.
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|---|---|
| ln Vitro |
N-Rosewood is an organic material.
In vitro, N-Piperidinoethanol is not typically studied for biological activity, as it is a chemical intermediate rather than a drug. Its primary use is as a reagent in organic synthesis. The compound's reactivity is characterized by its ability to undergo reactions typical of secondary alcohols and tertiary amines, including esterification, etherification, and quaternization. |
| ln Vivo |
In vivo, N-Piperidinoethanol is not used as a therapeutic agent. Its applications are limited to chemical synthesis and industrial uses.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays are not applicable to N-Piperidinoethanol, as it is not a drug with a specific biological target.
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| Cell Assay |
In vitro cellular assays are not applicable to N-Piperidinoethanol, as it is not a drug that interacts with cellular targets.
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| Animal Protocol |
In vivo animal studies are not applicable to N-Piperidinoethanol, as it is not a therapeutic agent.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of N-Piperidinoethanol indicate that it has a molecular weight of 129.20 and a molecular formula of C7H15NO. The compound is a colorless to pale yellow liquid with a boiling point of approximately 195-197°C. It is soluble in water and most organic solvents. For storage, the liquid should be kept under appropriate conditions to maintain stability. It is hygroscopic and should be protected from moisture.
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| Toxicity/Toxicokinetics |
Toxicological information for N-Piperidinoethanol is derived from its use as a chemical intermediate. It may cause skin and eye irritation. Inhalation of vapors may cause respiratory irritation. Standard laboratory safety precautions should be followed when handling the compound.
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| Additional Infomation |
2-(piperidin-1-yl)ethanol is a type of piperidine compound in which the hydrogen atom bonded to the nitrogen atom is replaced by a 2-hydroxyethyl group. It belongs to the piperidine class, tertiary amine class, primary alcohol class, and ethanolamine class.
N-Piperidinoethanol is an organic compound used as a building block in organic synthesis. It is used in the preparation of pharmaceuticals, agrochemicals, and other fine chemicals. The compound is also used as a corrosion inhibitor and catalyst. N-Piperidinoethanol is not a drug and is not approved for clinical use. |
| Molecular Formula |
C7H15NO
|
|---|---|
| Molecular Weight |
129.2
|
| Exact Mass |
129.115
|
| CAS # |
3040-44-6
|
| PubChem CID |
18232
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| Appearance |
Light yellow to brown liquid（Density：0.9732 g/cm3）
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| Density |
1.0±0.1 g/cm3
|
| Boiling Point |
200.5±0.0 °C at 760 mmHg
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| Melting Point |
16°C
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| Flash Point |
91.2±18.5 °C
|
| Vapour Pressure |
0.1±0.8 mmHg at 25°C
|
| Index of Refraction |
1.477
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| LogP |
1.06
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| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
9
|
| Complexity |
69.3
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
N1(CCO)CCCCC1
|
| InChi Key |
KZTWONRVIPPDKH-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C7H15NO/c9-7-6-8-4-2-1-3-5-8/h9H,1-7H2
|
| Chemical Name |
2-piperidin-1-ylethanol
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| Synonyms |
NSC-3460; NSC 3460; N-Piperidinoethanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.7399 mL | 38.6997 mL | 77.3994 mL | |
| 5 mM | 1.5480 mL | 7.7399 mL | 15.4799 mL | |
| 10 mM | 0.7740 mL | 3.8700 mL | 7.7399 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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