| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
N-Acetyl-DL-serine does not have a specific biological target as a drug. It is an amino acid derivative used in peptide synthesis and biochemical research. The acetyl group modification of serine can affect peptide folding, stability, and function. Acetylation plays a role in regulating protein interactions and gene expression. The compound's antimicrobial activity against Bacillus cereus and Staphylococcus aureus suggests potential interaction with bacterial targets, though this is not its primary application.
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| ln Vitro |
In vitro, N-Acetyl-DL-serine is used as a building block in peptide synthesis to introduce acetylated serine residues. It is valuable in research related to protein structure, enzyme activity, and cellular processes such as phosphorylation. The compound has demonstrated antimicrobial activity against Bacillus cereus and Staphylococcus aureus. It is used in studies of protein acetylation and its effects on protein function. However, specific pharmacological activity data are limited.
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| ln Vivo |
N-Acetyl-DL-serine does not have significant in vivo biological activity as a pharmacological agent. It is a biochemical reagent used in research. As an acetylated amino acid, it may be metabolized to serine and acetate in the body. Its antimicrobial activity suggests potential for in vivo effects, but specific efficacy data are not available. The compound is not used as a therapeutic agent.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays are not applicable to N-Acetyl-DL-serine as it is an amino acid derivative used in peptide synthesis, not a drug targeting a specific enzyme or receptor. Its characterization involves chemical analysis methods such as HPLC, NMR, and mass spectrometry. The compound's purity (typically ≥98%) is assessed by HPLC. No specific enzyme or receptor binding studies are reported.
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| Cell Assay |
Cell-based assays for N-Acetyl-DL-serine are limited. The compound may be used in cell culture as a component of peptide synthesis studies or to study the effects of acetylation on cellular processes. Its antimicrobial activity can be assessed in bacterial cultures. Minimum inhibitory concentration (MIC) assays can be performed against Bacillus cereus and Staphylococcus aureus. However, specific protocols are not extensively documented.
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| Animal Protocol |
In vivo animal experiments with N-Acetyl-DL-serine are not documented, as the compound is a research reagent and not a therapeutic agent. Its antimicrobial activity could potentially be evaluated in animal models of infection, but no such studies are reported. The compound is primarily used in biochemical research.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of N-Acetyl-DL-serine are not characterized, as it is not a therapeutic agent. The compound has a molecular formula of C5H9NO4 and a molecular weight of 147.13. It is highly soluble in water (1000 g/L at 25°C). It is a white to off-white crystalline powder. Storage: powder at -20°C for 3 years; in solvent at -80°C for 6 months.
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| Toxicity/Toxicokinetics |
Safety and toxicology data for N-Acetyl-DL-serine are limited. As an amino acid derivative, it is expected to have low toxicity. The compound is for research use only and is not for human therapeutic use. Standard laboratory safety precautions should be followed when handling the compound. No specific toxicity data are available.
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| Additional Infomation |
N-acetyl-DL-serine is an N-acyl amino acid. N-acetyl-DL-serine is a metabolite found or produced in Saccharomyces cerevisiae. See also: N-acetylserine (note moved here).
N-Acetyl-DL-serine has CAS number 97-14-3, molecular formula C5H9NO4, and molecular weight 147.13. It is an N-acetylated derivative of serine. It is a hydrophobic amino acid used in peptide synthesis. It has antimicrobial activity against Bacillus cereus and Staphylococcus aureus. Purity: ≥98%. Not for human use; for research purposes only. |
| Molecular Formula |
C5H9NO4
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|---|---|
| Molecular Weight |
147.12926
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| Exact Mass |
147.053
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| CAS # |
97-14-3
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| PubChem CID |
352294
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| Appearance |
White to off-white solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
468.4±40.0 °C at 760 mmHg
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| Melting Point |
131-132°C(lit.)
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| Flash Point |
237.1±27.3 °C
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| Vapour Pressure |
0.0±2.6 mmHg at 25°C
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| Index of Refraction |
1.494
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| LogP |
-1.89
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
10
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| Complexity |
145
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C(C(CO)NC(C)=O)O
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| InChi Key |
JJIHLJJYMXLCOY-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C5H9NO4/c1-3(8)6-4(2-7)5(9)10/h4,7H,2H2,1H3,(H,6,8)(H,9,10)
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| Chemical Name |
2-acetamido-3-hydroxypropanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~125 mg/mL (~849.59 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.7967 mL | 33.9836 mL | 67.9671 mL | |
| 5 mM | 1.3593 mL | 6.7967 mL | 13.5934 mL | |
| 10 mM | 0.6797 mL | 3.3984 mL | 6.7967 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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