| Size | Price | Stock | Qty |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
N-(3-Indolylacetyl)-L-alanine does not have a defined pharmacological target in mammalian systems. It is a plant growth regulator and a conjugate of the plant hormone indole-3-acetic acid (IAA) with the amino acid L-alanine. In plants, it may function as a storage or transport form of IAA, releasing the active hormone upon hydrolysis.
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| ln Vitro |
In vitro, N-(3-Indolylacetyl)-L-alanine appears to increase callus growth and reduces the ability of growths to differentiate into shoots of Phalaenopsis orchids. This demonstrates its activity as a plant growth regulator. Specific pharmacological activity data, such as IC50 values against mammalian targets, are not applicable as it is not a drug candidate.
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| ln Vivo |
In vivo applications of N-(3-Indolylacetyl)-L-alanine in animals are not typical, as it is a plant growth regulator. It is not used as a therapeutic agent in humans or animals. Its effects are studied in the context of plant physiology and development.
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| Enzyme Assay |
A cell-free assay for N-(3-Indolylacetyl)-L-alanine is not applicable as it is not an enzyme inhibitor. Its properties as a plant growth regulator can be characterized by studying its effects on plant tissue culture. Its identity and purity are typically confirmed by HPLC and other analytical methods.
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| Cell Assay |
Cellular experiments with N-(3-Indolylacetyl)-L-alanine are typically conducted in plant cell culture systems. Its effects on callus growth and shoot differentiation are studied in plant tissue culture. Mammalian cell-based assays are not applicable.
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| Animal Protocol |
In vivo animal experiments for N-(3-Indolylacetyl)-L-alanine are not applicable, as it is a plant growth regulator and not a therapeutic agent.
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| ADME/Pharmacokinetics |
N-(3-Indolylacetyl)-L-alanine has a molecular formula of C13H14N2O3 and a molecular weight of 246.26 g/mol. Its CAS number is 57105-39-2. The compound has an optical activity of [α]24/D −21° (c = 1 in methanol) and a melting point of 138-140°C. It is used in solution phase peptide synthesis. Specific pharmacokinetic properties are not applicable as it is not a therapeutic drug.
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| Toxicity/Toxicokinetics |
Toxicity data for N-(3-Indolylacetyl)-L-alanine are not provided in the available sources. As a plant growth regulator, it is not intended for human consumption. Standard laboratory safety precautions should be observed when handling this compound.
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| References | |
| Additional Infomation |
N-(indole-3-acetyl)-L-alanine is an N-acyl-L-amino acid, an N-indole-3-acetyl derivative of L-alanine. It is an indoleacetamide conjugate and also an N-acyl-L-alanine. IAA-L-Ala has been reported in tomato (Solanum lycopersicum), and relevant data are available for reference.
N-(3-Indolylacetyl)-L-alanine (CAS: 57105-39-2) is an indoleacetic acid amide conjugate. Its synonyms include Indole-3-acetyl-L-alanine and IAA-L-Ala. The compound is an N-acyl-L-amino acid and is used in plant physiology research. It is not a therapeutic drug and is strictly for research purposes. |
| Molecular Formula |
C13H14N2O3
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|---|---|
| Molecular Weight |
246.26186
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| Exact Mass |
246.1
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| CAS # |
57105-39-2
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| PubChem CID |
644225
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| Appearance |
White to off-white solid powder
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| Density |
1.33g/cm3
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| Boiling Point |
601.2ºC at 760 mmHg
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| Melting Point |
138-140ºC
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| Flash Point |
317.4ºC
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| Index of Refraction |
1.645
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| LogP |
1.69
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
18
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| Complexity |
332
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C[C@@H](C(=O)O)NC(=O)CC1=CNC2=CC=CC=C21
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| InChi Key |
FBDCJLXTUCMFLF-QMMMGPOBSA-N
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| InChi Code |
InChI=1S/C13H14N2O3/c1-8(13(17)18)15-12(16)6-9-7-14-11-5-3-2-4-10(9)11/h2-5,7-8,14H,6H2,1H3,(H,15,16)(H,17,18)/t8-/m0/s1
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| Chemical Name |
(2S)-2-[[2-(1H-indol-3-yl)acetyl]amino]propanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~1015.19 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.0607 mL | 20.3037 mL | 40.6075 mL | |
| 5 mM | 0.8121 mL | 4.0607 mL | 8.1215 mL | |
| 10 mM | 0.4061 mL | 2.0304 mL | 4.0607 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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