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| 5mg |
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| Targets |
Myricanol targets the microtubule-associated protein tau (MAPT), reducing its levels. It elicits growth inhibitory and cytotoxic effects on lung cancer cells and can significantly decelerate tumor growth in vivo by inducing apoptosis. The compound belongs to the class of flavonoids.
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| ln Vitro |
In vitro, Myricanol elicits growth inhibitory and cytotoxic effects on lung cancer cells. It reduces levels of microtubule-associated protein tau (MAPT). However, specific IC50 values and detailed in vitro activity data are not extensively reported.
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| ln Vivo |
In vivo, Myricanol can significantly decelerate tumor growth by inducing apoptosis. However, specific in vivo efficacy data and detailed animal study results are not extensively reported in the available literature.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays for Myricanol are not well-established. Its activity is assessed by measuring its effects on MAPT levels and its cytotoxic effects on cancer cells.
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| Cell Assay |
In vitro cellular assays for Myricanol are performed using lung cancer cell lines to assess its growth inhibitory and cytotoxic effects. Cells are treated with various concentrations of the compound, and cell viability and proliferation are assessed using MTT or CellTiter-Glo assays.
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| Animal Protocol |
In vivo animal studies with Myricanol would typically be conducted in mouse xenograft models of lung cancer to evaluate its antitumor efficacy. The compound would be administered, and tumor growth inhibition would be assessed. However, specific protocols are not detailed.
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| ADME/Pharmacokinetics |
The pharmacokinetic properties of Myricanol are not extensively reported. It has a molecular weight of 358.43. Specific parameters such as oral bioavailability, half-life, and tissue distribution are not detailed.
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| Toxicity/Toxicokinetics |
The toxicity profile of Myricanol is not extensively reported. As a research compound, it is for research use only and not for human therapeutic use. No specific toxicity data are detailed.
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| References | |
| Additional Infomation |
Myricanol has been reported to have been found in edible Morel bacteria, red Morel bacteria, and other organisms with available data.
Myricanol (CAS 33606-81-4) is a natural cyclic diarylheptanoid isolated from Myrica cerifera. It has a molecular formula of C21H26O5 and a molecular weight of 358.43. The compound elicits growth inhibitory and cytotoxic effects on lung cancer cells and decelerates tumor growth in vivo by inducing apoptosis. It is available for research purposes only. |
| Molecular Formula |
C21H26O5
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|---|---|
| Molecular Weight |
358.42814
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| Exact Mass |
358.178
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| CAS # |
33606-81-4
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| PubChem CID |
161779
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
583.5±50.0 °C at 760 mmHg
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| Flash Point |
306.7±30.1 °C
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| Vapour Pressure |
0.0±1.7 mmHg at 25°C
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| Index of Refraction |
1.591
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| LogP |
3.93
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
26
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| Complexity |
431
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| Defined Atom Stereocenter Count |
1
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| SMILES |
COC1=C2C=C(CCCC[C@H](CCC3=CC2=C(C=C3)O)O)C(=C1OC)O
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| InChi Key |
SBGBAZQAEOWGFT-OAHLLOKOSA-N
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| InChi Code |
InChI=1S/C21H26O5/c1-25-20-17-12-14(19(24)21(20)26-2)5-3-4-6-15(22)9-7-13-8-10-18(23)16(17)11-13/h8,10-12,15,22-24H,3-7,9H2,1-2H3/t15-/m1/s1
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| Chemical Name |
(9R)-16,17-dimethoxytricyclo[12.3.1.12,6]nonadeca-1(17),2,4,6(19),14(18),15-hexaene-3,9,15-triol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7899 mL | 13.9497 mL | 27.8995 mL | |
| 5 mM | 0.5580 mL | 2.7899 mL | 5.5799 mL | |
| 10 mM | 0.2790 mL | 1.3950 mL | 2.7899 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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