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    Mutant IDH1-IN-1
    Mutant IDH1-IN-1

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V3432
    CAS #: 1355326-21-4 Purity ≥98%

    Description: Mutant IDH1-IN-1 is a novel, potent and mutant-selective IDH1 (isocitrate dehydrogenase 1) inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively. Cancer-associated point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) confer a neomorphic enzymatic activity: the reduction of α-ketoglutarate to d-2-hydroxyglutaric acid, which is proposed to act as an oncogenic metabolite by inducing hypermethylation of histones and DNA. 

    References:  2015 Jan 9;290(2):762-74. 

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    Mutant IDH1-IN-1

    Name: Mutant IDH1-IN-1
    CAS#: 1355326-21-4
    Chemical Formula: C30H31FN4O2
    Exact Mass: 498.2431
    Molecular Weight: 498.6024
    Elemental Analysis: C, 72.27; H, 6.27; F, 3.81; N, 11.24; O, 6.42
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: Mutant IDH1-IN-1; Mutant IDH1-IN 1; Mutant IDH1 IN-1
    Chemical Name: 2-(N-[2-(Benzimidazol-1-yl)acetyl]-3-fluoroanilino)-N-cyclohexyl-2-(2-methylphenyl)acetamide
    InChi Key: DXYIOARJXVTYJW-UHFFFAOYSA-N
    InChi Code: InChI=1S/C30H31FN4O2/c1-21-10-5-6-15-25(21)29(30(37)33-23-12-3-2-4-13-23)35(24-14-9-11-22(31)18-24)28(36)19-34-20-32-26-16-7-8-17-27(26)34/h5-11,14-18,20,23,29H,2-4,12-13,19H2,1H3,(H,33,37)
    SMILES Code: O=C(NC1CCCCC1)C(N(C(CN2C3=CC=CC=C3N=C2)=O)C4=CC=CC(F)=C4)C5=CC=CC=C5C


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