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Purity: ≥98%
Motexafin lutetium hydrate (PCI-0123; Antrin; PCI0123; Lu texaphyrin; PCI 0123; LuTex; Lutetium texaphyrin; Lutrin; Optrin), the hydrated form of Motexafin lutetium, is a pentadentate aromatic metallotexaphyrin with photosensitizing properties. It is a photosensitiser used in photodynamic therapy to treat skin conditions and superficial cancers. It has also been tested for use in photoangioplasty (photodynamic treatment of diseased arteries). It is photoactivated by 732 nm light which allows greater depth of penetration.
| References |
Clinical Cancer Research. 2008,14(15): 4869–76.
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| Molecular Formula |
C52H74LUN5O15
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| Molecular Weight |
1166.12
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| CAS # |
156436-90-7
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| Related CAS # |
156436-90-7 (lutetium hydrate);246252-06-2 (gadolinium);189752-49-6 (free);
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| SMILES |
CCC1=C2N3C(C=C4C(CCCO)=C(C)C(C=[N]5C6=C7C=C(OCCOCCOCCOC)C(OCCOCCOCCOC)=C6)=[N]4[Lu+3]358([O-]C(C)=O)([O-]C(C)=O)[N]9=C(C=[N]78)C(C)=C(CCCO)C9=C2)=C1CC
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| Chemical Name |
[PB-7-11-233'2'4]-Bis[acetato-κO][9,10-diethyl-20,21-bis[2-[2-[2-methoxy-ethoxy]ethoxy]ethoxy]-4,15-dimethyl-8,11-imino-3,6:16,13-dinitrilo-1,18-benzodiazacycloeicosine-5,14-dipropanolato-κN1,κN18,κN23,κN24,κN25]-lutetium hydrate
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| Synonyms |
PCI-0123; Lutetium texaphyrin; Lu texaphyrin; PCI 0123; Lutrin; Optrin; PCI0123; LuTex; trade name: Antrin.
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.8575 mL | 4.2877 mL | 8.5754 mL | |
| 5 mM | 0.1715 mL | 0.8575 mL | 1.7151 mL | |
| 10 mM | 0.0858 mL | 0.4288 mL | 0.8575 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Time course of PSA response to PDT in patient 17 (A) and of the patient-averaged (mean ± SE) percent change in PSA after PDT (B).Clinical Cancer Research. 2008,14(15): 4869–76. |
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The average (mean ± SE) percent change in PSA, a function of time after PDT in patients who experienced a PDT dose less than (open bars) or greater than or equal to (closed bars), the median dose of 116 |
Kaplan-Meier estimation of biochemical delay in the PSA response in patients treated with a PDT dose less than or greater than or equal to the median dose of 116 |
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COA
PDT dose was calculated as the product of tissue photosensitizer concentration and light dose,n= 4 to 6 (open bars) or 7 to 8 (closed bars). +, =P< 0.06 for Wilcoxon signed-rank test comparing post-PDT PSA values to baseline measurement in the same patient.Clinical Cancer Research. 2008,14(15): 4869–76.
Duration of biochemical delay was defined as the length of time between PDT and a nonreversible (i.e., not PDT induced) increase in PSA to a value greater than or equal to baseline.n= 6 and 8 for low- and high-dose PDT, respectively.Clinical Cancer Research. 2008,14(15): 4869–76.