| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 500mg |
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| 1g |
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| Other Sizes |
| Targets |
Monopotassium glutamate primarily targets glutamate receptors in the body, which are involved in transmitting excitatory signals in the nervous system. It acts as an excitatory neurotransmitter in the central nervous system, playing a vital role in synaptic transmission. Glutamate is the most common excitatory neurotransmitter in the central nervous system.
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| ln Vitro |
In vitro, Monopotassium glutamate is a flavor enhancer and a food additive. It is a salt of glutamic acid. Its activity can be measured in cell-based assays using neuronal cells expressing glutamate receptors.
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| ln Vivo |
In vivo, Monopotassium glutamate can lower blood ammonia levels, plays a role in the metabolism of proteins and sugars in the brain, promotes oxidative processes, and improves central nervous system function. It can reduce the harmful effects of lithium.
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| Enzyme Assay |
Monopotassium glutamate is evaluated in cell-free assays as a reference standard for glutamate analysis. Its purity and identity can be confirmed using HPLC and other analytical techniques.
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| Cell Assay |
Monopotassium glutamate is assessed in cell-based assays using neuronal cells. Cells are treated with Monopotassium glutamate, and its effects on glutamate receptor signaling and cell function are measured.
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| Animal Protocol |
Monopotassium glutamate is administered orally in animal models and in human nutrition. It is used as a food additive to enhance flavor. Its effects on blood ammonia levels and central nervous system function have been studied.
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| ADME/Pharmacokinetics |
Monopotassium glutamate has a molecular weight of 185.22 and a molecular formula of C5H8KNO4. It has a CAS number of 19473-49-5. The compound is a solid. It is soluble in water and should be stored under recommended conditions.
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| Toxicity/Toxicokinetics |
Monopotassium glutamate is generally recognized as safe for use as a food additive. Human ingestion of 57 mg/kg causes headache. May cause irritation. The compound is a food additive and is not intended for therapeutic use.
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| References | |
| Additional Infomation |
Glutamate is a non-essential amino acid that naturally occurs among L-amino acids. Glutamate is the most common excitatory neurotransmitter in the central nervous system.
See also: Potassium glutamate (note moved to). Monopotassium glutamate is also known as L-Glutamic acid monopotassium salt and MPG. It is a flavor enhancer widely used in the food industry. The compound is not approved for clinical use. |
| Molecular Formula |
C5H8KNO4
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|---|---|
| Molecular Weight |
185.22
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| Exact Mass |
185.009
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| CAS # |
19473-49-5
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| Related CAS # |
56-86-0 (Parent)
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| PubChem CID |
23669634
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| Appearance |
Typically exists as solid at room temperature
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| Boiling Point |
333.8ºC at 760 mmHg
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| Flash Point |
155.7ºC
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
11
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| Complexity |
149
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C(CC(=O)[O-])[C@@H](C(=O)O)N.[K+]
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| InChi Key |
HQEROMHPIOLGCB-DFWYDOINSA-M
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| InChi Code |
InChI=1S/C5H9NO4.K/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1/t3-;/m0./s1
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| Chemical Name |
potassium;(2S)-2-amino-5-hydroxy-5-oxopentanoate
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| Synonyms |
Potassium glutamate; Monopotassium glutamate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.3990 mL | 26.9949 mL | 53.9898 mL | |
| 5 mM | 1.0798 mL | 5.3990 mL | 10.7980 mL | |
| 10 mM | 0.5399 mL | 2.6995 mL | 5.3990 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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