| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg | |||
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| Targets |
Mogroside I A1 targets metabolic and inflammatory pathways. Like Mogrol, it interacts with AMPK signaling pathways, promoting glucose uptake in skeletal muscle cells. This mechanism underpins the anti-hyperglycemic effects of monk fruit extracts. It also demonstrates antioxidant, anti-inflammatory, and metabolic regulatory activities.
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| ln Vitro |
In vitro, Mogroside I A1 demonstrates several biological activities. It exhibits antioxidant, antidiabetic, and anticancer properties in biochemical and cellular assays. Research suggests it may play a role in glucose homeostasis and oxidative stress reduction. Its activity is consistent with the broader class of mogrosides, which are known for these effects.
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| ln Vivo |
In vivo, Mogroside I A1 is believed to contribute to the overall health benefits of monk fruit. Studies on monk fruit extracts suggest potential benefits for glucose homeostasis, oxidative stress reduction, and cardiovascular support. As a purified compound, it is used to study these effects in a more controlled manner, though specific standalone in vivo data are limited.
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| Enzyme Assay |
The in vitro antioxidant assay for Mogroside I A1 involves measuring its ability to scavenge free radicals, such as DPPH or ABTS. The compound is incubated with the radical, and the decrease in absorbance is measured. For antidiabetic activity, its effect on glucose uptake in skeletal muscle cells can be measured using a fluorescent glucose analog like 2-NBDG.
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| Cell Assay |
In vitro cell culture studies for Mogroside I A1 utilize skeletal muscle cells to study glucose uptake. Cells are treated with the compound, and glucose uptake is measured. Adipocytes can be used to study its effects on adipogenesis and lipid accumulation. Its anti-inflammatory effects can be studied in macrophage cell lines by measuring cytokine production. Its anticancer activity is assessed in cancer cell lines using MTT assays.
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| Animal Protocol |
In vivo animal experiments for Mogroside I A1 are not extensively documented. However, its effects on glucose homeostasis could be studied in rodent models of type 2 diabetes, such as the db/db mouse or the high-fat diet-fed mouse. The compound would be administered orally, and its effect on blood glucose levels would be measured in an oral glucose tolerance test (OGTT).
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| ADME/Pharmacokinetics |
Mogroside I A1 has a molecular formula of C36H62O9 and a molecular weight of 638.87 g/mol. It is a solid compound that is soluble in water and organic solvents like DMSO. As a glycoside, it is more polar than its aglycone. It is typically stored as a powder at -20°C for long-term stability. Its stability is maintained under recommended storage conditions.
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| Toxicity/Toxicokinetics |
Toxicological data for Mogroside I A1 are limited, as it is a research compound. As a natural component of monk fruit, it is generally recognized as safe for human consumption at dietary levels. However, as a research compound, it is not intended for therapeutic use, and comprehensive toxicity studies are not available. Standard safety precautions should be followed.
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| References | |
| Additional Infomation |
Mogroside I-A1 is a mogroside with the structure mogroside, where the 24-hydroxyl hydrogen is replaced by a β-D-glucose group. It is a plant metabolite. It is a β-D-glucosinolate, a monosaccharide derivative, and also a type of mogroside. Its function is related to that of mogroside.
Mogroside I A1 is a research compound with no clinical approval. It is a valuable tool for studying the pharmacology of mogrosides and their potential applications in metabolic diseases. Its ability to promote glucose uptake and its antioxidant properties make it a compound of interest for research into diabetes and metabolic syndrome. |
| Molecular Formula |
C34H58O9
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|---|---|
| Molecular Weight |
610.81892
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| Exact Mass |
638.439
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| CAS # |
88901-46-6
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| Related CAS # |
3α-Hydroxymogroside IA1
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| PubChem CID |
101135270
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| Appearance |
White to light yellow solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
762.5±60.0 °C at 760 mmHg
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| Flash Point |
415.0±32.9 °C
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| Vapour Pressure |
0.0±5.8 mmHg at 25°C
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| Index of Refraction |
1.581
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| LogP |
3.86
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| Hydrogen Bond Donor Count |
7
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| Hydrogen Bond Acceptor Count |
9
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| Rotatable Bond Count |
8
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| Heavy Atom Count |
45
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| Complexity |
1110
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| Defined Atom Stereocenter Count |
15
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| SMILES |
C[C@H](CC[C@H](C(C)(C)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)[C@H]2CC[C@@]3([C@@]2(C[C@H]([C@@]4([C@H]3CC=C5[C@H]4CC[C@@H](C5(C)C)O)C)O)C)C
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| InChi Key |
UNCMRQFSKAVFQU-QZGPORMMSA-N
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| InChi Code |
InChI=1S/C36H62O9/c1-19(9-14-27(33(4,5)43)45-31-30(42)29(41)28(40)23(18-37)44-31)20-15-16-34(6)24-12-10-21-22(11-13-25(38)32(21,2)3)36(24,8)26(39)17-35(20,34)7/h10,19-20,22-31,37-43H,9,11-18H2,1-8H3/t19-,20-,22-,23-,24+,25+,26-,27-,28-,29+,30-,31+,34+,35-,36+/m1/s1
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| Chemical Name |
(2S,3R,4S,5S,6R)-2-[(3R,6R)-6-[(3S,8S,9R,10R,11R,13R,14S,17R)-3,11-dihydroxy-4,4,9,13,14-pentamethyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-hydroxy-2-methylheptan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~156.53 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6371 mL | 8.1857 mL | 16.3714 mL | |
| 5 mM | 0.3274 mL | 1.6371 mL | 3.2743 mL | |
| 10 mM | 0.1637 mL | 0.8186 mL | 1.6371 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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