| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
|
||
| 100mg |
|
||
| 250mg |
|
||
| 500mg | |||
| Other Sizes |
| Targets |
Modaline sulfate targets monoamine transporters and receptors. It may inhibit the reuptake of dopamine, norepinephrine, and serotonin, leading to increased synaptic concentrations of these neurotransmitters. It may also release monoamines from nerve terminals. It may have agonist activity at certain monoamine receptors.
|
|---|---|
| ln Vitro |
In vitro, modaline sulfate has been shown to inhibit the uptake of dopamine, norepinephrine, and serotonin in synaptosomal preparations. It may also stimulate the release of these neurotransmitters. It can affect cell viability and signaling in neuronal cell cultures.
|
| ln Vivo |
In vivo, modaline sulfate has been studied in animal models for its antidepressant and psychostimulant effects. It may increase locomotor activity and produce behavioral effects similar to other stimulants. It has been studied in models of depression and other psychiatric disorders.
|
| Enzyme Assay |
For non-cellular enzyme/receptor binding assays, modaline sulfate can be tested for affinity to monoamine transporters and receptors using radioligand binding assays. Inhibition of monoamine uptake can be measured using synaptosomal preparations and radiolabeled neurotransmitters.
|
| Cell Assay |
For in vitro cell-based assays, neuronal cell lines are cultured and treated with modaline sulfate. Neurotransmitter uptake and release are measured. Cell viability, signaling pathway activation, and gene expression can be assessed.
|
| Animal Protocol |
For in vivo animal studies, modaline sulfate can be administered orally or intraperitoneally to animal models. Behavioral assays for antidepressant and stimulant activity (such as forced swim test, open field test, and conditioned place preference) can be used. Neurochemical measurements of monoamine levels can be performed.
|
| ADME/Pharmacokinetics |
Pharmacokinetic properties include solubility in water and DMSO. It is a small molecule and is likely absorbed orally. It is metabolized in the liver and excreted. Storage is typically at -20°C. It is a solid and should be handled with standard laboratory precautions.
|
| Toxicity/Toxicokinetics |
Toxicological data for modaline sulfate is limited. As a stimulant, it may have adverse effects such as increased heart rate, blood pressure, anxiety, and insomnia. It may have abuse potential. It is not for human use in research settings.
|
| Additional Infomation |
Modaline sulfate is a synthetic compound studied as a potential antidepressant and psychostimulant. It inhibits the reuptake of dopamine, norepinephrine, and serotonin. It may have effects on monoamine neurotransmitter systems. It has been studied in animal models of depression and other psychiatric disorders.
|
| Molecular Formula |
C10H15N3.H2O4S
|
|---|---|
| Molecular Weight |
275.32468
|
| Exact Mass |
275.094
|
| CAS # |
2856-75-9
|
| PubChem CID |
17859
|
| Appearance |
Light yellow to green yellow solid powder
|
| Boiling Point |
294.2ºC at 760mmHg
|
| Flash Point |
131.7ºC
|
| Vapour Pressure |
0.00165mmHg at 25°C
|
| LogP |
2.268
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
7
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
18
|
| Complexity |
236
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
GJXZNORUUOVBKP-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C10H15N3.H2O4S/c1-9-10(12-6-5-11-9)13-7-3-2-4-8-13;1-5(2,3)4/h5-6H,2-4,7-8H2,1H3;(H2,1,2,3,4)
|
| Chemical Name |
2-methyl-3-piperidin-1-ylpyrazine;sulfuric acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 31 mg/mL (~112.60 mM)
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6321 mL | 18.1607 mL | 36.3214 mL | |
| 5 mM | 0.7264 mL | 3.6321 mL | 7.2643 mL | |
| 10 mM | 0.3632 mL | 1.8161 mL | 3.6321 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
