Size | Price | Stock | Qty |
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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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2g |
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5g |
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Other Sizes |
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Purity: ≥98%
Metirosine (α-Methyltyrosine, Metyrosine, AMPT) is an antihypertensive drug that acts by inhibiting the enzyme tyrosine hydroxylase and, therefore, catecholamine synthesis, which, as a consequence, depletes the levels of the catecholamines dopamine, adrenaline and noradrenaline in the body. Metirosine has been shown to suppress catecholamine synthesis and alleviate symptoms related to catecholamine excess, including hypertension, headache, tachycardia, constipation, and tremor. Metirosine is primarily used to reduce these symptoms in patients with pheochromocytoma. It is contraindicated for the treatment of essential hypertension. However it is now rarely used in medicine, its primary use being in scientific research to investigate the effects of catecholamine depletion on behavior. There is evidence that catecholamine depletion causes a increase in sleepiness that is more pronounced than sleep deprivation, and that the fatigue lingers after the drug is discontinued. Negative mood is also a reported side effect of catecholamine depletion, although this is reported less consistently than sleepiness.
ln Vitro |
Metyrosine induces sleep by blocking tyrosine kinases, which releases stored catecholamines [2].
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ln Vivo |
Carrageenan modulator is lowered by metyrosine (50–200 mg/kg; ip) [1]. Male albino Wistar rats with carrageenan-induced rat paw edema are the animal model of resistance to the anti-activity of metyrosine (50–200 mg/kg; ip) at dosages of 50, 100, and 200 mg/kg [2].
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Animal Protocol |
Animal/Disease Models: Male albino Wistar rats (carrageenan-induced rat paw edema)[2]
Doses: 50, 100 or 200 mg/kg Route of Administration: I.p. Experimental Results: diminished carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h). |
References |
[1]. Albayrak A, Polat B, Cadirci E, et al. Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats. Pharmacol Rep. 2010;62(1):113‐119.
[2]. Garg MK, et al. Medical management of pheochromocytoma: Role of the endocrinologist. Indian J Endocrinol Metab. 2011;15 Suppl 4(Suppl4):S329‐S336. |
Molecular Formula |
C10H13NO3
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Molecular Weight |
195.2151
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CAS # |
672-87-7
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SMILES |
O=C(O)[C@@](C)(N)CC1=CC=C(O)C=C1
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InChi Key |
NHTGHBARYWONDQ-JTQLQIEISA-N
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InChi Code |
InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1
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Chemical Name |
(S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
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Synonyms |
Demser; Metirosine; Racemetirosine; α-Methyltyrosine
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ~5 mg/mL (~25.61 mM)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 5.1224 mL | 25.6121 mL | 51.2243 mL | |
5 mM | 1.0245 mL | 5.1224 mL | 10.2449 mL | |
10 mM | 0.5122 mL | 2.5612 mL | 5.1224 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.