| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Following surface treatment, the herbicide can be absorbed through the leaves, but the primary absorption pathway is through the roots. …Root absorption is best described as osmotic diffusion. When the herbicide is applied to the leaf base, it is transported upwards in the xylem and moves distally. After absorption, it is rapidly distributed and excreted in its original form or via urine after metabolism (oxidation). Metabolism/Metabolites When 14C-labeled methamidophos is applied to tomatoes, preliminary evidence suggests that the first 14C-labeled metabolite may be deaminated diketone methamidophos or a complex of methamidophos. When methamidophos is applied to the roots of soybean (Glycine max (Leguminatae) Merr. 'Cutler') seedlings, it is rapidly absorbed and transported to the aboveground parts. The major product observed is deaminated methamidophos. 3,5-Diketone derivatives and deamination-dione derivatives were also observed. The identities of these metabolites were determined by cochromatographic and mass spectrometric analysis. These compounds were produced in both roots and stems. The aglycones of the four acid-labile carbohydrate conjugates formed were identified as 3,5-Diketone derivatives and deamination-dione derivatives. Potatoes were planted in soil treated with metribuzin. Analysis of the plant material revealed the presence of metribuzin, 3,5-Diketone derivatives, deamination-dione derivatives, and conjugates. Analysis indicated that deamination-dione was the aglycone of one of the conjugates. When these studies were repeated in the same soil, another metabolite was found in the aboveground parts of the plant and identified as trimethylpyruvate hemi-aminourea. Similar results were observed in carrots and their growing soil. |
|---|---|
| Toxicity/Toxicokinetics |
Non-Human Toxicity Values
Oral LD50 in rats: 1100 mg/kg Dermal LD50 in rats: >2000 mg/kg Dermal LD50 in rabbits: >2000 mg/kg Oral LD50 in mice: 698-711 mg/kg For more complete (16) non-human toxicity values for metribuzin, please visit the HSDB record page. |
| Additional Infomation |
Metribuzin is a colorless crystalline solid used as a herbicide. (NIOSH, 2024)
Metribuzin belongs to the 1,2,4-triazine class of compounds, with the structure 1,2,4-triazine-5(4H)-one, substituted with an amino group at position 4, a tert-butyl group at position 6, and a methylthio group at position 3. It can be used as an exogenous substance, environmental pollutant, herbicide, and agrochemical. It belongs to the 1,2,4-triazine class of compounds, organosulfur compounds, and cyclic ketones. Metribuzin (4-amino-6-tert-butyl-3-(methylthio)-triazine-5(4H)-one) is a herbicide used for pre- and post-emergence weed control in crops such as soybeans, potatoes, tomatoes, and sugarcane. Its mechanism of action is to inhibit photosynthesis by disrupting photosystem II. It is widely used in agriculture, but has been found to pollute groundwater. Mechanism of Action Inhibition of photosynthesis |
| Molecular Formula |
C8H14N4OS
|
|---|---|
| Exact Mass |
214.088
|
| CAS # |
21087-64-9
|
| PubChem CID |
30479
|
| Appearance |
Colorless crytals
White crystalline solid |
| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
312.4±25.0 °C at 760 mmHg
|
| Melting Point |
125°C
|
| Flash Point |
142.7±23.2 °C
|
| Vapour Pressure |
0.0±0.7 mmHg at 25°C
|
| Index of Refraction |
1.618
|
| LogP |
1.3
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
14
|
| Complexity |
316
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O=C1N(C(SC)=NN=C1C(C)(C)C)N
|
| InChi Key |
FOXFZRUHNHCZPX-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C8H14N4OS/c1-8(2,3)5-6(13)12(9)7(14-4)11-10-5/h9H2,1-4H3
|
| Chemical Name |
4-amino-6-tert-butyl-3-methylsulfanyl-1,2,4-triazin-5-one
|
| Synonyms |
Metribuzin DIC 1468 Sencor
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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