| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg | |||
| 25mg | |||
| Other Sizes |
| Targets |
The molecular targets of Melittoside are not well-characterized, as the compound is primarily used as a research reagent. As a natural iridoid glycoside, it may interact with various biological targets, including enzymes and receptors involved in cellular signaling. Iridoids are known for their diverse biological activities, including anti-inflammatory, antioxidant, and neuroprotective effects. However, specific targets for Melittoside have not been identified in the literature. The compound is used as a reference standard for the identification and quantification of iridoids in natural products.
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|---|---|
| ln Vitro |
In vitro studies of Melittoside are limited, as the compound is primarily used as a research reagent rather than a pharmacologically active compound. It is used as a reference standard in analytical chemistry for the identification and quantification of iridoids in natural products. The compound's stability in biological samples and its behavior under various analytical conditions have been characterized. No specific biological activities have been reported for Melittoside in the available literature. The compound is typically used in metabolomics and natural product research.
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| ln Vivo |
In vivo studies of Melittoside are limited, as the compound is primarily used as a research reagent. No specific pharmacological or toxicological in vivo studies have been reported. The compound is found in various plants and may contribute to their therapeutic effects. However, the specific role of Melittoside in the plant's pharmacological effects has not been established. The compound is used for research purposes only and is not intended for therapeutic use.
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| Enzyme Assay |
For analytical characterization, Melittoside is typically analyzed using high-performance liquid chromatography (HPLC) coupled with UV or mass spectrometry detection. The compound is dissolved in an appropriate solvent (e.g., methanol, DMSO, or water) and injected onto a suitable column (e.g., C18 reverse-phase column). The mobile phase typically consists of water and acetonitrile or methanol with a gradient elution. The compound is detected at a suitable wavelength (e.g., 210-254 nm) or by mass spectrometry. For quantification, external calibration curves or internal standards are used. For structural characterization, NMR spectroscopy and mass spectrometry are employed to confirm the identity and purity of the compound.
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| Cell Assay |
For cellular studies, Melittoside is typically not used in standard cell culture experiments due to its role as a reference standard rather than a pharmacological agent. However, in metabolomics studies, cells may be treated with extracts containing Melittoside, and the compound's levels are measured by LC-MS. No specific cellular assays have been reported for this compound.
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| Animal Protocol |
For in vivo studies in animal models, Melittoside is typically not administered as a test compound. However, in metabolomics studies, animals may be treated with plant extracts, and Melittoside levels in blood and tissues are measured by LC-MS. No specific dosing or administration protocols are reported in the literature.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for Melittoside are not available, as the compound is used as a research reagent rather than a therapeutic agent. As a natural iridoid glycoside with a molecular weight of 524.47, the compound is expected to have low oral bioavailability due to poor absorption and extensive metabolism. However, no dedicated pharmacokinetic studies have been reported.
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| Toxicity/Toxicokinetics |
No toxicological data for Melittoside have been reported, as the compound is a natural product used primarily as a research reagent. As with all research compounds, appropriate safety precautions should be taken when handling Melittoside, including the use of personal protective equipment and work in a well-ventilated area.
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| References | |
| Additional Infomation |
Melittoside are glycoside compounds belonging to the iridoid monoterpenoid class. They have been reported to be found in Rehmannia glutinosa, Crataegus pinnatifida, and other organisms with relevant data.
Melittoside (CAS 19467-03-9) is a glycoside and an iridoid monoterpenoid. It has a molecular formula of C₂₁H₃₂O₁₅ and a molecular weight of 524.47. The compound is a natural product used as a reference standard in natural product research. It is a glycoside and an iridoid monoterpenoid. Melittoside is typically stored as a powder. The compound is used in metabolomics and natural product research. It is strictly for research use only. |
| Molecular Formula |
C21H32O15
|
|---|---|
| Molecular Weight |
524.4698
|
| Exact Mass |
524.174
|
| CAS # |
19467-03-9
|
| PubChem CID |
11968737
|
| Appearance |
White to light yellow solid powder
|
| Density |
1.8±0.1 g/cm3
|
| Boiling Point |
890.0±65.0 °C at 760 mmHg
|
| Melting Point |
167-168 ºC
|
| Flash Point |
492.1±34.3 °C
|
| Vapour Pressure |
0.0±0.6 mmHg at 25°C
|
| Index of Refraction |
1.699
|
| LogP |
-5.4
|
| Hydrogen Bond Donor Count |
10
|
| Hydrogen Bond Acceptor Count |
15
|
| Rotatable Bond Count |
7
|
| Heavy Atom Count |
36
|
| Complexity |
823
|
| Defined Atom Stereocenter Count |
14
|
| SMILES |
C1=CO[C@H]([C@H]2[C@@]1([C@@H](C=C2CO)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O
|
| InChi Key |
LZKBAGSBRBMVBE-GVKBFFPQSA-N
|
| InChi Code |
InChI=1S/C21H32O15/c22-4-7-3-10(25)21(36-20-17(31)15(29)13(27)9(6-24)34-20)1-2-32-18(11(7)21)35-19-16(30)14(28)12(26)8(5-23)33-19/h1-3,8-20,22-31H,4-6H2/t8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18+,19+,20+,21-/m1/s1
|
| Chemical Name |
(2S,3R,4S,5S,6R)-2-[[(1S,4aS,5R,7aR)-5-hydroxy-7-(hydroxymethyl)-4a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,7a-dihydro-1H-cyclopenta[c]pyran-1-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 50 mg/mL (~95.33 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9067 mL | 9.5334 mL | 19.0669 mL | |
| 5 mM | 0.3813 mL | 1.9067 mL | 3.8134 mL | |
| 10 mM | 0.1907 mL | 0.9533 mL | 1.9067 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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