Dexmedetomidine HCl [(S)-Medetomidine]

Alias: Dexmedetomidine HCl; Dexmedetomidine Hydrochloride; Precedex
Cat No.:V1143 Purity: ≥98%
Dexmedetomidine HCl (Precedex), the hydrochloride salt of Dexmedetomidine which is the dexter isomer of medetomidine, is a highly selective and potent alpha-2 adrenoceptor agonist with sedative effects.
Dexmedetomidine HCl [(S)-Medetomidine] Chemical Structure CAS No.: 145108-58-3
Product category: Adrenergic Receptor
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
10mg
25mg
50mg
100mg
250mg
500mg
1g
Other Sizes

Other Forms of Dexmedetomidine HCl [(S)-Medetomidine]:

  • Dexmedetomidine
  • Medetomidine (MPV-785)
  • Medetomidine HCl (MPV-785)
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Dexmedetomidine HCl (Precedex), the hydrochloride salt of Dexmedetomidine which is the dexter isomer of medetomidine, is a highly selective and potent alpha-2 adrenoceptor agonist with sedative effects. It reduces anesthetic requirements for patients by providing significant sedation. Dexmedetomidine has a relatively high ratio of α2/α1-activity (1620:1 as compared with 220:1 for clonidine) and, therefore, is considered a full agonist of the α2 receptor. This may result in more potent effects of sedation without unwanted cardiovascular effects from α1 receptor activation.

Biological Activity I Assay Protocols (From Reference)
Targets
α2-adrenergic receptor ( IC50 = 1.08 nM )
ln Vitro

In vitro activity: Medetomidine has a high degree of selectivity, as determined by the displacement of [3H]clonidine, for α2 adrenoceptors (Ki=1.08 nM) over α1 adrenoceptors (Ki=1750 nM) in rat brain membranes[1].
Medetomidine (0.1-100 nM) suppresses the twitch response in field-stimulated mouse vas deferens, with a pD2 of 9.0[1].

ln Vivo
Medetomidine (10-100 μg/kg; i.v. at 5-min intervals) causes a dose-dependent dilation of the pupils in rats given pentobarbitone[1].
Animal Protocol
Female Sprague-Dawley rats (270-350 g)
1, 5, 10, 50, 100 mg/kg
I.v. at 5-min intervals
References

[1]. Eur J Pharmacol . 1988 May 20;150(1-2):9-14.

[2]. Proc (Bayl Univ Med Cent) . 2001 Jan;14(1):13-21.

[3]. J Anaesthesiol Clin Pharmacol . 2019 Jan-Mar;35(1):36-40.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C13H17CLN2
Molecular Weight
236.74
Exact Mass
236.11
Elemental Analysis
C, 65.95; H, 7.24; Cl, 14.97; N, 11.83
CAS #
145108-58-3
Appearance
Solid powder
SMILES
CC1=C(C(=CC=C1)[C@H](C)C2=CN=CN2)C.Cl
InChi Key
VPNGEIHDPSLNMU-MERQFXBCSA-N
InChi Code
InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1
Chemical Name
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole;hydrochloride
Synonyms
Dexmedetomidine HCl; Dexmedetomidine Hydrochloride; Precedex
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: 40~250 mg/mL (199.7~1056.0 mM)
Water: ~40 mg/mL (~199.7 mM)
Ethanol:~40 mg/mL (~199.7 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 4.2240 mL 21.1202 mL 42.2404 mL
5 mM 0.8448 mL 4.2240 mL 8.4481 mL
10 mM 0.4224 mL 2.1120 mL 4.2240 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

Molarity Calculator allows you to calculate the mass, volume, and/or concentration required for a solution, as detailed below:

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An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?
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Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:
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g/mol

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

Clinical Trial Information
NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04635098 Active
Recruiting
Drug: dexmedetomidine
Drug: saline
Chronic Insomnia Ruijin Hospital May 14, 2021 Not Applicable
NCT02952222 Active
Recruiting
Drug: Dexmedetomidine
Drug: Propofol (Group P)
Anesthesia Keira Mason May 11, 2018 Phase 4
NCT03522688 Active
Recruiting
Drug: Dexmedetomidine
Drug: Normal saline
Acute Kidney Injury
Liver Diseases
Asan Medical Center July 11, 2017 Phase 4
NCT03933306 Active
Recruiting
Drug: Dexmedetomidine
Drug: Placebo
Blood Pressure
Dexmedetomidine
High-risk Patients
Peking University First Hospital May 20, 2019 Phase 4
NCT05671081 Active
Recruiting
Drug: Dexmedetomidine
Drug: Magnesium sulfate
Drug: Narcotic Analgesics
Anesthesia , Analgesia Ain Shams University January 5, 2023 Phase 3
Biological Data
  • Dexmedetomidine HCl
    Immunofluorescence staining of phosphorylated ERK1/2 in astrocyte cultures.Br J Pharmacol. 2008 May; 154(1): 191–203.
  • Dexmedetomidine HCl
    Src kinase is involved in dexmedetomidine-induced, but not EGF-induced ERK1/2 phosphorylation in astrocytes.Br J Pharmacol. 2008 May; 154(1): 191–203.
  • Dexmedetomidine HCl
    Dexmedetomidine-induced protein expression of cFos and FosB requires EGF receptor and ERK action in astrocytes.Br J Pharmacol. 2008 May; 154(1): 191–203.
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