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    Dexmedetomidine HCl [(S)-Medetomidine]
    Dexmedetomidine HCl [(S)-Medetomidine]

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1143
    CAS #: 145108-58-3Purity ≥98%

    Description: Dexmedetomidine HCl (Precedex), the hydrochloride salt of Dexmedetomidine which is the dexter isomer of medetomidine, is a highly selective and potent alpha-2 adrenoceptor agonist with sedative effects. It reduces anesthetic requirements for patients by providing significant sedation. Dexmedetomidine has a relatively high ratio of α2/α1-activity (1620:1 as compared with 220:1 for clonidine) and, therefore, is considered a full agonist of the α2 receptor. This may result in more potent effects of sedation without unwanted cardiovascular effects from α1 receptor activation.

    References: Eur J Pharmacol. 1988 May 20;150(1-2):9-14; Anesthesiology. 1997 Feb;86(2):331-45.

    Related CAS #: 145108-58-3 (HCl)   113775-47-6 (free base)   

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    Molecular Weight (MW)236.74
    FormulaC13H16N2.HCl 
    CAS No.145108-58-3
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 40 mg/mL (199.7 mM) 
    Water: 40 mg/mL (199.7 mM) 
    Ethanol: 40 mg/mL (199.7 mM) 
    Other info

    Chemical Name: 5-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole;hydrochloride

    InChi Key: VPNGEIHDPSLNMU-MERQFXBCSA-N

    InChi Code: InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1

    SMILES Code: C[[email protected]](C1=CN=CN1)C2=CC=CC(C)=C2C.[H]Cl

    SynonymsDexmedetomidine HCl; Dexmedetomidine Hydrochloride; Precedex; 


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    In Vitro

    In vitro activity: Dexmedetomidine has a relatively high ratio of α2/α1-activity (1620:1 as compared with 220:1 for clonidine) and, therefore, is considered a full agonist of the α2 receptor. This may result in more potent effects of sedation without unwanted cardiovascular effects from α1 receptor activation. The 2-h half-life of dexmedetomidine is nearly 4-fold shorter than that of clonidine, which increases the likelihood that a continuous infusion of dexmedetomidine might be useful for sedation. Dexmedetomidine also has minimum alveolar anesthetic concentration (MAC)-sparing properties, but its use as an anesthetic adjuvant has been complicated by persistent hypotension that has mandated IV fluid administration and vasopressor administration. In addition, its use in large doses is complicated by hypertension from α2 receptor-mediated vascular constriction.

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    References

    Eur J Pharmacol. 1988 May 20;150(1-2):9-14; Anesthesiology. 1997 Feb;86(2):331-45. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     
    Dexmedetomidine HCl
    Immunofluorescence staining of phosphorylated ERK1/2 in astrocyte cultures. Br J Pharmacol. 2008 May; 154(1): 191–203.
     
    Dexmedetomidine HCl
    Src kinase is involved in dexmedetomidine-induced, but not EGF-induced ERK1/2 phosphorylation in astrocytes. Br J Pharmacol. 2008 May; 154(1): 191–203.
     
    Dexmedetomidine HCl
    Dexmedetomidine-induced protein expression of cFos and FosB requires EGF receptor and ERK action in astrocytes. Br J Pharmacol. 2008 May; 154(1): 191–203.


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