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    InvivoChem Cat #: V1146
    CAS #: 113775-47-6Purity ≥98%

    Description: Dexmedetomidine (trade name Precedex), the dexter isomer of medetomidine, is a potent and highly selective alpha-2 adrenergic receptor agonist with sedative activities. Dexmedetomidine reduces anesthetic requirements for patients by providing significant sedation.  

    References: Eur J Pharmacol. 1988 May 20;150(1-2):9-14; Anesthesiology. 1997 Feb;86(2):331-45.

    elated CAS #: 145108-58-3 (HCl)   113775-47-6 (free base)   

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    Molecular Weight (MW)200.28
    CAS No.113775-47-6 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 40 mg/mL (199.7 mM) 
    Water: 40 mg/mL (199.7 mM) 
    Ethanol: 40 mg/mL (199.7 mM) 
    Other info

    Chemical Name: 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole


    InChi Code: InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1

    SMILES Code: CC1=C(C(=CC=C1)[[email protected]](C)C2=CN=CN2)C

    SynonymsDexmedetomidine HCl; Dexmedetomidine Hydrochloride; Precedex; 

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    In Vitro

    In vitro activity: Dexmedetomidine has a relatively high ratio of α2/α1-activity (1620:1 as compared with 220:1 for clonidine) and, therefore, is considered a full agonist of the α2 receptor. This may result in more potent effects of sedation without unwanted cardiovascular effects from α1 receptor activation. The 2-h half-life of dexmedetomidine is nearly 4-fold shorter than that of clonidine, which increases the likelihood that a continuous infusion of dexmedetomidine might be useful for sedation. Dexmedetomidine also has minimum alveolar anesthetic concentration (MAC)-sparing properties, but its use as an anesthetic adjuvant has been complicated by persistent hypotension that has mandated IV fluid administration and vasopressor administration. In addition, its use in large doses is complicated by hypertension from α2 receptor-mediated vascular constriction.

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    Eur J Pharmacol. 1988 May 20;150(1-2):9-14; Anesthesiology. 1997 Feb;86(2):331-45. 

    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Immunofluorescence staining of phosphorylated ERK1/2 in astrocyte cultures. Br J Pharmacol. 2008 May; 154(1): 191–203.

    Src kinase is involved in dexmedetomidine-induced, but not EGF-induced ERK1/2 phosphorylation in astrocytes. Br J Pharmacol. 2008 May; 154(1): 191–203.

    Dexmedetomidine-induced protein expression of cFos and FosB requires EGF receptor and ERK action in astrocytes. Br J Pharmacol. 2008 May; 154(1): 191–203.


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