| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| Targets |
Malachite Green Carbinol base does not have a specific biological receptor or enzyme target. Its mechanism of action is based on its chemical properties as a pH indicator and dye rather than engagement with a pharmacological target. The compound can release OH- under UV light irradiation, generating a progressive shift in pH values. Its potential biological effects are likely related to its ability to interact with cellular components as a cationic dye, but no specific molecular target has been identified in the context of drug discovery.
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| ln Vitro |
Malachite green methanol base (MGOH, MGCB) is a colorless hydroxide derivative of triphenylmethane that functions as a photoinduced hydroxyl ion emitter. Used to dye silk, wool, jute, leather, and cotton. Also used as a biological stain, fungicide/parasiticide for fish[1][2].
In vitro, Malachite Green Carbinol base is characterized by its photochemical properties rather than pharmacological activity. Under high-pressure UV lamp irradiation (500 W, 50 W/cm), the MGCB solution rapidly turns from colorless to deep green. This color change is indicative of the pH-dependent properties of the compound. However, specific in vitro pharmacological activity data, such as IC50 values against cell lines or enzyme targets, are not available in the literature, as the compound is primarily used as a chemical reagent rather than a therapeutic agent. |
| ln Vivo |
Specific in vivo activity data for Malachite Green Carbinol base are not available in the scientific literature. The compound has historical applications in various industries including aquaculture, but its systemic use has been limited due to safety concerns. As a chemical dye and pH indicator, it is not administered as a therapeutic agent in living organisms. No in vivo pharmacological studies have been reported for this compound.
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| Enzyme Assay |
A cell-free assay for Malachite Green Carbinol base is not applicable as it is not an enzyme inhibitor or receptor ligand. The compound's properties are characterized by spectrophotometric methods to measure its colorimetric and pH-responsive characteristics. Its ability to release OH- under UV irradiation can be assessed by monitoring pH changes in solution. The purity of the compound for research use is typically ≥90% as determined by HPLC.
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| Cell Assay |
Cellular experiments with Malachite Green Carbinol base are not typical, as the compound is not used as a pharmacologically active agent in cell-based assays. Its primary applications are as a chemical dye and pH indicator. Potential cellular studies would focus on its staining properties or pH-modulating effects rather than pharmacological activity. No specific cell-based protocols are described in the available literature.
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| Animal Protocol |
In vivo animal experiments for Malachite Green Carbinol base are not described in the available sources. The compound is not used as a therapeutic agent in animal models. Its historical use in aquaculture has been limited due to safety concerns. No preclinical studies have been reported for this compound.
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| ADME/Pharmacokinetics |
Malachite Green Carbinol base (CAS: 510-13-4) is a small molecule with a molecular weight of 346.47 and a molecular formula of C23H26N2O. Its IUPAC name is bis(4-(dimethylamino)phenyl)(phenyl)methanol. The compound is a solid at room temperature with a melting point of 163-168°C. For long-term storage, it should be kept in a cool, dry place. Pharmacokinetic properties are not applicable as it is not a therapeutic drug.
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| Toxicity/Toxicokinetics |
Malachite Green Carbinol base is considered to have safety concerns, which have limited its use in various applications including aquaculture. Specific toxicological data, such as LD50 values, are not provided in the available sources. As a chemical dye, it should be handled with appropriate safety precautions. The compound is intended for research use only and is not for human consumption.
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| References | |
| Additional Infomation |
Malachite green methanol is a benzene-based aromatic compound.
Malachite Green Carbinol base (CAS: 510-13-4) is a non-fluorescent derivative of malachite green also known as Solvent Green 1. It functions as a pH regulation reagent that releases OH- under UV light irradiation. The compound has a purity of ≥90% (HPLC) and appears as a solid with a melting point of 163-168°C. Its molecular formula is C23H26N2O and its molecular weight is 346.47. It is not an approved drug and is strictly for research purposes as a chemical reagent and dye. |
| Molecular Formula |
C23H26N2O
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| Molecular Weight |
346.46
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| Exact Mass |
346.205
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| CAS # |
510-13-4
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| PubChem CID |
10521
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| Appearance |
Green to dark green solid powder
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| Density |
1.131g/cm3
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| Boiling Point |
526.2ºC at 760mmHg
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| Melting Point |
112-114ºC
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| Flash Point |
268.2ºC
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| Index of Refraction |
1.635
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| LogP |
4.102
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
26
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| Complexity |
386
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
LXHOGENDFZKPSF-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C23H26N2O/c1-24(2)21-14-10-19(11-15-21)23(26,18-8-6-5-7-9-18)20-12-16-22(17-13-20)25(3)4/h5-17,26H,1-4H3
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| Chemical Name |
bis[4-(dimethylamino)phenyl]-phenylmethanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8863 mL | 14.4317 mL | 28.8634 mL | |
| 5 mM | 0.5773 mL | 2.8863 mL | 5.7727 mL | |
| 10 mM | 0.2886 mL | 1.4432 mL | 2.8863 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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