| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
D-Lysine hydrochloride does not have a specific pharmacological target. It is used as a research tool to study amino acid transporters, stereospecificity in biological systems, and as a non-metabolizable analog of L-lysine in certain experimental setups.
|
|---|---|
| ln Vitro |
D-Lysine hydrochloride is not typically evaluated for biological activity in the same way as a drug. It can be used to study the stereospecificity of enzymes and transporters that interact with lysine.
|
| ln Vivo |
D-Lysine hydrochloride is not a therapeutic agent and is not administered for pharmacological effects in vivo. It is used in research settings to study amino acid metabolism and transport.
|
| Enzyme Assay |
The in vitro activity of D-lysine hydrochloride can be assessed in assays measuring its interaction with amino acid transporters. Cells expressing specific transporters are incubated with radiolabeled or fluorescently labeled D-lysine, and the uptake is measured.
|
| Cell Assay |
D-Lysine hydrochloride can be used in cell culture to study the effects of amino acid stereoisomers on cellular metabolism. Cells are cultured in media containing D-lysine, and its effects on cell growth, metabolism, or gene expression are assessed.
|
| Animal Protocol |
D-Lysine hydrochloride is not administered in animal models for therapeutic purposes. It may be used in pharmacokinetic studies to investigate the absorption and distribution of D-amino acids.
|
| ADME/Pharmacokinetics |
D-Lysine hydrochloride has a molecular weight of 182.65 g/mol and a molecular formula of C6H14N2O2·HCl. It is a white crystalline powder that is freely soluble in water.
|
| Toxicity/Toxicokinetics |
D-Lysine hydrochloride is generally considered to have low toxicity. As an amino acid, it is not expected to be highly toxic. However, high doses may cause gastrointestinal disturbances.
|
| References | |
| Additional Infomation |
D-Lysine hydrochloride is the hydrochloride of D-lysine, containing D-lysine residues.
D-Lysine hydrochloride is a research compound used in biochemical and pharmacological studies. It is not a drug and is not approved for clinical use. It is primarily used to study amino acid metabolism, transport, and stereospecificity. |
| Molecular Formula |
C6H15CLN2O2
|
|---|---|
| Molecular Weight |
182.6485
|
| Exact Mass |
182.082
|
| CAS # |
7274-88-6
|
| Related CAS # |
D-Lysine;923-27-3;D-Lysine-d4 monohydrochloride;2714413-18-8
|
| PubChem CID |
81691
|
| Appearance |
White to off-white solid powder
|
| Boiling Point |
311.5ºC at 760 mmHg
|
| Melting Point |
266ºC (dec.)
|
| Flash Point |
142.2ºC
|
| LogP |
1.729
|
| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
5
|
| Heavy Atom Count |
11
|
| Complexity |
106
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
C(CCN)C[C@H](C(=O)O)N.Cl
|
| InChi Key |
BVHLGVCQOALMSV-NUBCRITNSA-N
|
| InChi Code |
InChI=1S/C6H14N2O2.ClH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m1./s1
|
| Chemical Name |
(2R)-2,6-diaminohexanoic acid;hydrochloride
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~100 mg/mL (~547.50 mM)
DMSO :< 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.4750 mL | 27.3748 mL | 54.7495 mL | |
| 5 mM | 1.0950 mL | 5.4750 mL | 10.9499 mL | |
| 10 mM | 0.5475 mL | 2.7375 mL | 5.4750 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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