| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 100mg | |||
| Other Sizes |
| Targets |
Lyoniresinol-3-O-glucopyranoside has been reported to have antibacterial activity against Gram-positive bacteria. It functions as an antibacterial agent and antifungal agent. The compound also exhibits superoxide dismutase-like activity and antioxidant properties.
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| ln Vitro |
In vitro, Lyoniresinol-3-O-glucopyranoside demonstrates antibacterial activity against Gram-positive bacteria. It also exhibits antioxidant activity and superoxide dismutase-like properties. The compound has been used in studies of Gram-positive bacterial infections.
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| ln Vivo |
In vivo, Lyoniresinol-3-O-glucopyranoside has been studied for its potential therapeutic effects. Its antibacterial and antioxidant activities suggest potential applications in infectious diseases and oxidative stress-related conditions. Further studies are needed to fully characterize its in vivo efficacy.
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| Enzyme Assay |
In vitro antibacterial assays typically measure the minimum inhibitory concentration (MIC) of Lyoniresinol-3-O-glucopyranoside against Gram-positive bacterial strains. Bacteria are cultured in appropriate medium and treated with serial dilutions of the compound. Antioxidant activity is assessed using DPPH or ABTS radical scavenging assays.
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| Cell Assay |
In vitro cellular assays evaluate the compound's effects on bacterial cells or mammalian cells. For antibacterial activity, bacterial growth inhibition is measured. For antioxidant activity, the compound's ability to protect cells from oxidative stress is assessed. Cytotoxicity assays may be performed to evaluate the safety profile.
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| Animal Protocol |
In vivo animal experiments for Lyoniresinol-3-O-glucopyranoside are limited. The compound is a natural product with potential antibacterial and antioxidant activities. Further studies in animal models of infection or oxidative stress would be needed to confirm its in vivo efficacy and safety.
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| ADME/Pharmacokinetics |
Lyoniresinol-3-O-glucopyranoside has a molecular formula of C28H38O13 and a molecular weight of 582.6. It is also known as (+)-Lyoniresinol 9'-O-glucoside and (+)-Lyoniresinol 3α-O-β-D-glucopyranoside. The compound has a purity of ≥98%. It is soluble in appropriate organic solvents.
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| Toxicity/Toxicokinetics |
The toxicity profile of Lyoniresinol-3-O-glucopyranoside is not well documented. As a natural product, it is expected to have a favorable safety profile. However, comprehensive toxicological studies would be required for therapeutic development. The compound is used primarily as a research reagent.
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| References | |
| Additional Infomation |
(+)-Lyonresinol-3-α-O-β-D-glucopyranoside is a lignan formed by the substitution of (+)-Lyonresinol at the 3-position with a β-D-glucopyranoside via a glycosidic bond. It was isolated from the root bark of Stemmadenia minima and Lycium chinense and possesses antibacterial activity. It functions as a metabolite, antibacterial agent, and antifungal agent. It is a β-D-glucoside, dimethoxybenzene, lignan, primary alcohol, monosaccharide derivative, polyphenol, and tetrahydronaphthalene compound. Its function is related to (+)-Lyonresinol. (+)-Lyonresinol-3-α-O-β-D-glucopyranoside has been reported in Acanthus ilicifolius, Acanthus ebracteatus, and other organisms with relevant data.
Lyoniresinol-3-O-glucopyranoside is a natural product isolated from various plant sources including Lycium barbarum, Stemmadenia minima, and Aegle marmelos. It has demonstrated antibacterial and antioxidant activities. The compound is used in research on Gram-positive bacterial infections and oxidative stress-related conditions. |
| Molecular Formula |
C28H38O13
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|---|---|
| Molecular Weight |
582.59352
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| Exact Mass |
582.231
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| CAS # |
87585-32-8
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| PubChem CID |
10483388
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.5±0.1 g/cm3
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| Boiling Point |
797.2±60.0 °C at 760 mmHg
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| Flash Point |
435.9±32.9 °C
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| Vapour Pressure |
0.0±2.9 mmHg at 25°C
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| Index of Refraction |
1.648
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| LogP |
-1.81
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| Hydrogen Bond Donor Count |
7
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| Hydrogen Bond Acceptor Count |
13
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| Rotatable Bond Count |
10
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| Heavy Atom Count |
41
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| Complexity |
791
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| Defined Atom Stereocenter Count |
8
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| SMILES |
COC1=CC(=CC(=C1O)OC)C2C(C(CC3=CC(=C(C(=C23)OC)O)OC)CO)COC4C(C(C(C(O4)CO)O)O)O
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| InChi Key |
PQQRNPDHSJDAGV-HQSXISOASA-N
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| InChi Code |
InChI=1S/C28H38O13/c1-36-16-7-13(8-17(37-2)22(16)31)20-15(11-40-28-26(35)25(34)23(32)19(10-30)41-28)14(9-29)5-12-6-18(38-3)24(33)27(39-4)21(12)20/h6-8,14-15,19-20,23,25-26,28-35H,5,9-11H2,1-4H3/t14-,15-,19+,20+,23+,25-,26+,28+/m0/s1
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| Chemical Name |
(2R,3R,4S,5S,6R)-2-[[(1S,2R,3R)-7-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-3-(hydroxymethyl)-6,8-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7165 mL | 8.5824 mL | 17.1647 mL | |
| 5 mM | 0.3433 mL | 1.7165 mL | 3.4329 mL | |
| 10 mM | 0.1716 mL | 0.8582 mL | 1.7165 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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