| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 100mg | |||
| Other Sizes |
| Targets |
Lubabegron targets β-adrenergic receptors, specifically β1 and β2 adrenergic receptors. It acts as an agonist at these receptors, activating signaling pathways that promote protein synthesis and muscle growth.
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|---|---|
| ln Vitro |
In vitro, lubabegron activates β-adrenergic receptors, leading to increased cAMP production and activation of protein kinase A. This results in enhanced protein synthesis and reduced protein degradation in muscle cells.
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| ln Vivo |
In vivo, lubabegron improves growth performance and feed efficiency in livestock. It promotes muscle growth and reduces fat deposition. The compound is used as a growth promoter in beef cattle.
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| Enzyme Assay |
In vitro receptor binding assays typically measure the displacement of a radiolabeled β-adrenergic receptor ligand from membrane preparations. Lubabegron is incubated with membranes and a radioactive tracer, and the IC50 or Ki is determined. Functional assays measure cAMP accumulation in cells expressing β-adrenergic receptors.
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| Cell Assay |
In vitro cellular assays evaluate the effects of lubabegron on muscle cell lines. Cells are treated with the compound, and protein synthesis is measured by incorporation of radiolabeled amino acids. cAMP levels are measured to confirm receptor activation.
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| Animal Protocol |
In vivo animal experiments are conducted in livestock, such as beef cattle. Lubabegron is administered orally as a feed additive, and growth performance is assessed by measuring body weight gain, feed efficiency, and carcass composition.
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| ADME/Pharmacokinetics |
Lubabegron has a molecular formula of C22H28N2O3 and a molecular weight of 368.47. It has a CAS number of 391920-32-4. The compound is a β-adrenergic receptor agonist used in veterinary medicine.
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| Toxicity/Toxicokinetics |
The toxicity profile of lubabegron is consistent with that of other β-adrenergic agonists. Potential side effects may include cardiovascular effects such as increased heart rate and palpitations. The compound is approved for use in livestock with established withdrawal periods.
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| References | |
| Additional Infomation |
See also: Lubaberon fumarate (active ingredient); Lubaberon; Monensin (ingredient); Lubaberon; Monensin; Tylosin (ingredient)... View more...
Lubabegron is a veterinary drug used as a growth promoter in beef cattle. It is a β-adrenergic receptor agonist that improves growth performance and feed efficiency. The compound is also known as a beta-agonist for livestock production. |
| Molecular Formula |
C29H29N3O3S
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|---|---|
| Molecular Weight |
499.629
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| Exact Mass |
499.193
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| CAS # |
391920-32-4
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| Related CAS # |
391926-19-5 (fumarate);391920-32-4;391920-33-5 (HCl);
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| PubChem CID |
60085980
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| Appearance |
White to off-white solid powder
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| LogP |
6.215
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
11
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| Heavy Atom Count |
36
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| Complexity |
705
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| Defined Atom Stereocenter Count |
1
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| SMILES |
CC(C)(CC1=CC=C(C=C1)OC2=C(C=CC=N2)C#N)NC[C@@H](COC3=CC=CC=C3C4=CC=CS4)O
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| InChi Key |
WIKLBKJBYSBYLL-QHCPKHFHSA-N
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| InChi Code |
InChI=1S/C29H29N3O3S/c1-29(2,17-21-11-13-24(14-12-21)35-28-22(18-30)7-5-15-31-28)32-19-23(33)20-34-26-9-4-3-8-25(26)27-10-6-16-36-27/h3-16,23,32-33H,17,19-20H2,1-2H3/t23-/m0/s1
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| Chemical Name |
(S)-2-(4-(2-((2-hydroxy-3-(2-(thiophen-2-yl)phenoxy)propyl)amino)-2-methylpropyl)phenoxy)nicotinonitrile
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| Synonyms |
LY488756 LY-488756 LY 488756 Lubabegron
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~200.15 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0015 mL | 10.0074 mL | 20.0148 mL | |
| 5 mM | 0.4003 mL | 2.0015 mL | 4.0030 mL | |
| 10 mM | 0.2001 mL | 1.0007 mL | 2.0015 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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