| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
Longifolene does not have a specific pharmacological target. It is a natural product with potential biological activities. It has been studied for its role in drug development, with some promising results in preclinical studies. However, its mechanism of action is not well-defined.
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|---|---|
| ln Vitro |
Longifolene is not a pharmacologically active compound in the traditional sense. Its in vitro activity is related to its chemical properties and potential biological interactions. It may be used in studies of enzyme inhibition or as a starting material for synthesis.
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| ln Vivo |
Longifolene is not used in vivo as a pharmacological agent. Its applications are primarily in research and industry. It is not administered to animals or humans for therapeutic purposes.
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| Enzyme Assay |
Longifolene does not have an enzyme/receptor binding assay. It is a natural product used in research. Its potential biological activities can be studied in cell-free or cell-based systems. However, these are not standard pharmacological assays.
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| Cell Assay |
Longifolene is used in cellular assays to study its potential biological activities. Its effects on cell viability, enzyme activity, or signaling pathways can be assessed. However, these are not standard pharmacological assays.
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| Animal Protocol |
Longifolene is not used in animal studies as a pharmacological agent. Its applications are primarily in research and industry.
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| ADME/Pharmacokinetics |
Longifolene is not administered systemically as it is not a drug. Therefore, pharmacokinetic properties such as absorption, distribution, metabolism, and excretion are not applicable.
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| Toxicity/Toxicokinetics |
Longifolene is a natural product and is generally considered to have low toxicity. However, it may be irritating to skin and eyes. Standard laboratory safety precautions should be taken when handling this compound.
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| References | |
| Additional Infomation |
Longifolene is a sesquiterpene. It has been reported that longifolene is found in European red pine, swamp pine, and other organisms with relevant data.
Longifolene is a naturally occurring tricyclic sesquiterpene found in pine resins. It has potential applications in medical and industrial research. It is one of the aroma constituents of lapsang souchong tea. It is not a pharmaceutical agent. |
| Molecular Formula |
C15H24
|
|---|---|
| Molecular Weight |
204.35
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| Exact Mass |
204.187
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| CAS # |
475-20-7
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| PubChem CID |
289151
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| Appearance |
Colorless to light yellow liquid
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| Density |
0.9±0.1 g/cm3
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| Boiling Point |
252.2±7.0 °C at 760 mmHg
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| Flash Point |
101.1±0.0 °C
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| Vapour Pressure |
0.0±0.2 mmHg at 25°C
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| Index of Refraction |
1.508
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| LogP |
6.39
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
0
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
15
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| Complexity |
312
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC1(CCC[C@@]2(C([C@@H]3CC[C@@H]2[C@H]13)=C)C)C
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| InChi Key |
PDSNLYSELAIEBU-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C15H24/c1-10-11-6-7-12-13(11)14(2,3)8-5-9-15(10,12)4/h11-13H,1,5-9H2,2-4H3
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| Chemical Name |
3,3,7-trimethyl-8-methylidenetricyclo[5.4.0.02,9]undecane
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~489.36 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8936 mL | 24.4678 mL | 48.9356 mL | |
| 5 mM | 0.9787 mL | 4.8936 mL | 9.7871 mL | |
| 10 mM | 0.4894 mL | 2.4468 mL | 4.8936 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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